Results 41 to 50 of about 3,617 (206)

The burden of COVID‐19 in hospitalized people with diabetes mellitus in Brazil: Insights from four years of the pandemic

Diabetic Medicine, EarlyView.
Abstract Aims Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is more severe in people with diabetes mellitus due to immune dysfunction, exacerbated inflammation and increased risk of co‐morbidities and mortality.
Taís Mendes Camargo, Bianca Aparecida Siqueira, Luiz Felipe Azevedo Marques, Lucas Silva Mello, Fernando Augusto Lima Marson   +4 more
wiley   +1 more source

Cardiovascular-kidney-metabolic syndrome in Indonesia: a commentary on the need for integrated management and policy action

Frontiers in Public Health
Cardiovascular-kidney-metabolic (CKM) syndrome is a term introduced to reflect the multidirectional relationship between metabolic disorders, kidney disease, and cardiovascular disease (CVD).
Sally Aman Nasution, Sally Aman Nasution, Eka Ginanjar, Eka Ginanjar, Aida Lydia, Aida Lydia, Lugyanti Sukrisman, Lugyanti Sukrisman, Idrus Alwi, Idrus Alwi, Ika Prasetya Wijaya, Ika Prasetya Wijaya, Charles Limantoro, Charles Limantoro, Haerani Rasyid, Haerani Rasyid, Pringgodigdo Nugroho, Pringgodigdo Nugroho, Wachid Putranto, Wachid Putranto, Ketut Suastika, Ketut Suastika, Soebagijo Adi Soelistijo, Soebagijo Adi Soelistijo, Tri Juli Edi Tarigan, Tri Juli Edi Tarigan, Icha Farihah Deniyati Faratisha   +26 more
doaj   +1 more source

Hyperaldosteronism in the Pathophysiology and Management of Cardiovascular‐Kidney‐Metabolic Syndrome

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular‐kidney‐metabolic (CKM) syndrome is defined by the pathologic interconnections between obesity, diabetes, chronic kidney disease and cardiovascular disease. An important and underrecognized pathophysiologic factor underlying CKM syndrome is obesity‐induced aldosterone excess.
Evan Zeitler, Klara R. Klein, Ildiko Lingvay, Anthony Pick, Liana K. Billings   +4 more
wiley   +1 more source

Effects of Vicadrostat/Empagliflozin in People With Chronic Kidney Disease: Metabolic Subgroup Analyses

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims In a phase 2 trial, the efficacy and safety of the highly selective aldosterone synthase inhibitor vicadrostat, alone or with empagliflozin, were investigated in people with chronic kidney disease (CKD) with or without type 2 diabetes (T2D). Materials and Methods Adults (n = 586) with CKD (estimated glomerular filtration rate [eGFR] 30 to
David Z. I. Cherney, Peter Rossing, Maria Eugenia Canziani, Maria Luiza Caramori, Ricardo Correa‐Rotter, Lisa Cronin, Christian Hugo, Bo Ji, Juliane Meyerhoff, Masaomi Nangaku, Arnold Silva, Dorothea Urbach, Shimoli V. Shah, Dick de Zeeuw, Katherine R. Tuttle   +14 more
wiley   +1 more source

Associations between Life’s Crucial 9 and severity, all-cause mortality, and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: the mediating role of phenotypic age acceleration

Frontiers in Nutrition
ObjectiveThe American Heart Association (AHA) recently introduced the concept of cardiovascular-kidney-metabolic (CKM) syndrome. This study aimed to explore the associations of Life’s Crucial 9 (LC9), the recently updated lifestyle guidelines for ...
Jing Li, Jing Li, Jing Li, Zengxin Xu, Zengxin Xu, Zengxin Xu, Jiayi Lin, Shunxiang Luo, Shanghua Xu   +8 more
doaj   +1 more source

Association between dietary index for gut microbiota and cardiovascular-kidney-metabolic syndrome: a population-based study

Frontiers in Nutrition
BackgroundCardiovascular-kidney-metabolic (CKM) syndrome represents a major health threat globally. The newly proposed dietary index for gut microbiota (DI-GM), which quantifies dietary quality associated with gut microbiota diversity, may influence the ...
Dan Long, Chenhan Mao, Haoyu An, Ying Zhu, Yin Xu   +4 more
doaj   +1 more source

Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment [PDF]

, 2013
Background: Biopsies taken from individual tumours exhibit extensive differences in their cellular composition due to the inherent heterogeneity of cancers and vagaries of sample collection.
Doig, Tamasin, Freeman, Tom C, Goodlad, John, Gregory, Christopher D, Hume, David A, Theocharidis, Thanos   +5 more
core   +2 more sources

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Association of hemoglobin glycation index with the severity and mortality of cardiovascular-kidney-metabolic syndrome: a population-based cohort study

Cardiovascular Diabetology. Endocrinology Reports
Background Cardiovascular-kidney-metabolic (CKM) syndrome is a recently proposed multisystem disorder with high prevalence and progressive stages from 0 to 4, characterized by uncertain risk factors.
Leiluo Geng, Xue Diao, Hong-jie Yu, Aimin Xu   +3 more
doaj   +1 more source

Searching for realistic 4d string models with a Pati-Salam symmetry -- Orbifold grand unified theories from heterotic string compactification on a Z6 orbifold

, 2004
Motivated by orbifold grand unified theories, we construct a class of three-family Pati-Salam models in a Z6 abelian symmetric orbifold with two discrete Wilson lines.
Aldazabal, Aldazabal, Allanach, Altarelli, Amaldi, Angelantonj, Angelantonj, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Aoki, Aoki, Asaka, Atick, Bailin, Bailin, Bailin, Banks, Barbieri, Becker, Becker, Brignole, Brignole, Brignole, Burwick, Campbell, Candelas, Cardoso, Casas, Casas, Casas, Casas, Casas, Casas, Casas, Chaudhuri, Cleaver, Cleaver, Cleaver, de Wit, Derendinger, Dermíšek, Dienes, Dienes, Dienes, Dimopoulos, Dimopoulos, Dine, Dine, Dine, Dine, Distler, Dixon, Dixon, Dixon, Dixon, Ellis, Erler, Erler, Faraggi, Faraggi, Font, Font, Font, Font, Font, Forste, Freed, Friedan, Friedan, Georgi, Ghilencea, Ghilencea, Giedt, Giunti, Giveon, Gliozzi, Green, Green, Greene, Greene, Grinstein, Gross, Gross, Gross, Hall, Hall, Hall, Hall, Hamidi, Harvey, Hebecker, Henningson, Hořava, Hořava, Ibáñez, Ibáñez, Ibáñez, Ibáñez, Ibáñez, Kakushadze, Kakushadze, Kaplunovsky, Kaplunovsky, Kaplunovsky, Kaplunovsky, Katsuki, Kawai, Kawamura, Kim, Kim, Knizhnik, Ko, Kobayashi, Kobayashi, Kobayashi, Kobayashi, Kobayashi, Kobayashi, Kobayashi, Langacker, Leontaris, Lerche, Lerche, Lewellen, Lopes Cardoso, Lucas, Lüst, Lüst, Marshak, Masiero, Mayr, Mayr, Mayr, Mohaupt, Murayama, Narain, Narain, Nilles, Pati, Polchinski, Ren-Jie Zhang, Schellekens, Schellekens, Spalinski, Stieberger, Stuart Raby, Tatsuo Kobayashi, Tsutsui, Uranga, Vafa, Witten, Witten   +153 more
core   +1 more source