Results 41 to 50 of about 1,152,205 (156)
BMC Cardiovascular DisordersBackground The American Heart Association introduced cardiovascular-kidney-metabolic (CKM) syndrome, a highly prevalent multistage comorbidity in the U.S.
Jing Zhang, Dingyuan Tu
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A guide to transcriptional cyclin‐dependent kinases in cancer
The FEBS Journal, EarlyView.Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin +2 more
wiley +1 more source
The oral mucosal and salivary microbial community of Behçet's syndrome and recurrent aphthous stomatitis. [PDF]
, 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is ...
Bergmeier, LA +9 more
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Experimental Physiology, EarlyView.Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu +5 more
wiley +1 more source
American Journal of Preventive CardiologyBackground: Cardiac, kidney, and metabolic diseases are associated with a short life expectancy. However, the potential impact of the cardiovascular-kidney-metabolic (CKM) syndrome, recently introduced by the American Heart Association (AHA), on life ...
Zhendong Cheng +7 more
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Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes
Experimental Physiology, EarlyView.Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou +11 more
wiley +1 more source
Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype
Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 9809-9818, November 2026.ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
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Frontiers in Public HealthBackgroundThe relationship between shift work, occupational physical activity (OPA), and CKM syndrome remains unclear. The present study aimed to investigate the independent and joint associations of these two factors with CKM syndrome.MethodsThis study ...
Xiangran Zhang +12 more
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Lifestyle Medicine, Volume 7, Issue 4, October 2026.ABSTRACT Background Workplace lifestyle programs are increasingly used for early cardiovascular–kidney–metabolic prevention but are commonly evaluated as whole packages. Whether distinct adherence domains within a multimodal program are associated with different short‐term health responses remains unclear.
Hao Hsu +5 more
wiley +1 more source
Biology of Sex DifferencesCardiovascular–kidney–metabolic (CKM) syndrome represents a continuum of interrelated adiposity, insulin resistance, cardiovascular disease, kidney dysfunction, and metabolic disturbances that evolve across the lifespan.
Aline M. A. de Souza +5 more
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