Results 41 to 50 of about 4,881 (175)

Structural, mechanistic and regulatory studies of serine palmitoyltransferase [PDF]

, 2012
SLs (sphingolipids) are composed of fatty acids and a polar head group derived from l-serine. SLs are essential components of all eukaryotic and many prokaryotic membranes but S1P (sphingosine 1-phosphate) is also a potent signalling molecule.
Alexeev, An, Astner, Bejaoui, Bourquin, Breslow, Buede, Dietrich, Dominic J. Campopiano, Eliot, Fahy, Gable, Gable, Gable, Garofalo, Geiger, Han, Han, Han, Hanada, Hanada, Hanada, Hjelmqvist, Hojjati, Hornemann, Hornemann, Huang, Ikushiro, Ikushiro, Ikushiro, Jahan, James H. Naismith, Jonathan Lowther, Kawahara, Kelly, Lowther, Lowther, Merrill, Mun, Nagiec, Nagiec, Penno, Raman, Raman, Roelants, Rotthier, Schmidt, Shiraiwa, Snell, Teresa M. Dunn, Ternes, Weiss, Williams, Yard, Yim, Zhao, Zitomer   +56 more
core   +1 more source

3-Benzylidene-1′-methyl-4′-phenyldispiro[cyclopentane-1,3′-pyrrolidine-2′,1′′-acenaphthene]-2,2′′-dione

IUCrData, 2017
In the title compound, C33H27NO2, the pyrrolidine ring adopts an envelope conformation, with the N atom as the flap. The cyclopentanone ring adopts a twisted conformation about the Cs—CH2 bond (s = spiro link). The dihedral angle between these rings (all
E. Varadharajan, V. Ramkumar, M. V. B. Scholastica, Arul Prasad T. Augustine   +3 more
doaj   +1 more source

(E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one

Molbank, 2021
Imidazole-containing chalcones have been shown to be strongly effective against Aspergillusfumigatus, the causative agent for the disease pulmonary aspergillosis. Claisen–Schmidt condensation of 4-(1H-imidazol-1-yl)benzaldehyde with 4′-methylacetophenone
Nicholas Bailey, Bradley O. Ashburn
doaj   +1 more source

Heteroatom-Synergistic Effect on Anchoring Polysulfides In Chalcone-Linked Nanographene Covalent Organic Frameworks for High-Performance Li─S Batteries. [PDF]

Adv Sci (Weinh)
A series of nanographene‐type covalent organic framework sulfur‐hosting cathodes are developed by introducing pyridine and chalcone functionalities to amend strong lithium polysulfides (LiPSs) interactions to suppress the shuttle effect in lithium‐sulfur (Li─S) batteries. The cathode material showed a specific capacity of 1228 mA h g−1 at 0.5C with 80%
Ranjeesh KC, Javaregowda BH, Gaber S, Bhauriyal P, Kumar S, Skorjanc T, Finšgar M, Heine T, Krishnamoorthy K, Shetty D.   +9 more
europepmc   +2 more sources

Aspergillus westerdijkiae polyketide synthase gene “aoks1” is involved in the biosynthesis of ochratoxin A [PDF]

, 2009
OchratoxinA (OTA) is a potential nephrotoxic, teratogenic, immunogenic, hepatotoxic and carcinogenic mycotoxin, produced by Aspergillus westerdijkiae NRRL 3174.
Atoui, Ali, Bacha, Nafees, Lebrihi, Ahmed, Liboz, Thierry, Mathieu, Florence   +4 more
core   +2 more sources

Synthesis and Identification of Phenyl Azochalcone & bis- azo – Chalcone Derivatives Derived from P-amino Acetophenone [PDF]

Kirkuk Journal of Science, 2018
This work involves the synthesis of different substituted amino-chalcones via claisen- schmidt condensation reaction between p-amino acetophenone and different aromatic substituted benzaldehydes. The second step involves the conversion of amino-chalcones
Zahraa Talib Ghlib, Ahmed Abdul-Hassan, Nihad Ismael Taha   +2 more
doaj   +1 more source

(E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(3-chloro-4-fluorophenyl)prop-2-en-1-one

Molbank, 2022
Imidazole-containing chalcones have been shown to be effective against Aspergillus fumigatus, the pathogenic agent for pulmonary aspergillosis. Claisen-Schmidt condensation of 4-(1H-imidazol-1-yl)benzaldehyde with 3′-chloro-4′-fluoroacetophenone using ...
Reina Takaki, Bradley O. Ashburn
doaj   +1 more source

Ionic Liquids as Carbene Catalyst Precursors in the One-Pot Four-Component Assembly of Oxo Triphenylhexanoates (OTHOs) [PDF]

, 2015
Ionic liquids (ILs) are a convenient and inexpensive source of N-heterocyclic carbenes (NHCs). In this study, dialkyl imidazolium-based ILs are used as carbene precursors in a four-component synthesis of oxo triphenylhexanoates (OTHOs), where it was ...
Axelsson, Anton, Sundén, Henrik, Ta, Linda   +2 more
core   +2 more sources

Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives

Natural Sciences, Volume 6, Issue 2, April 2026.
ABSTRACT Breast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use. In this work, we synthesized six chalcone derivatives with alkoxy‐ and methylthio‐substituents through Claisen–Schmidt condensation at room temperature.
Nurcahyo Iman Prakoso, Taiki Umezawa, Dwiarso Rubiyanto, Azizah Zelia Kusumo, Fanny Septianingtyas, Muhamad Ikhsan Nurochman, Laras Kristianti, Salmahaminati, Pinus Jumaryatno, Minori Abe   +9 more
wiley   +1 more source

Synthesis and Characterization of Novel Heterocyclic Chalcones from 1-Phenyl-1H-pyrazol-3-ol

Molecules, 2022
An efficient synthetic route to construct diverse pyrazole-based chalcones from 1-phenyl-1H-pyrazol-3-ols bearing a formyl or acetyl group on the C4 position of pyrazole ring, employing a base-catalysed Claisen–Schmidt condensation reaction, is described.
Arminas Urbonavičius, Graziana Fortunato, Emilija Ambrazaitytė, Elena Plytninkienė, Aurimas Bieliauskas, Vaida Milišiūnaitė, Renzo Luisi, Eglė Arbačiauskienė, Sonata Krikštolaitytė, Algirdas Šačkus   +9 more
doaj   +1 more source