Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers [PDF]
Flavonoids are a large family of compounds associated with a broad range of biologically useful properties. In recent years, synthetic compounds that contain two flavonoid units linked together have attracted attention in drug discovery and development ...
Collins, S +6 more
core +3 more sources
This graphical abstract highlights the molecular framework, electronic features, and nonlinear optical response of the quinolinone–chalcone crystal QCCP. The left panel displays the full molecular structure and the electrostatic environment introduced by iterative charge embedding, illustrating the crystal‐packing–induced dipole enhancement observed in
Clodoaldo Valverde +9 more
wiley +1 more source
Ab initio study of the mechanism of carboxylic acids cross-ketonization on monoclinic zirconia via condensation to beta-keto acids followed by decarboxylation [PDF]
Catalytic mechanism of acetic and isobutyric acids mixture conversion into two symmetrical and one cross-ketone product on monoclinic zirconia (111) surface was extensively modeled by Density Functional Theory for periodic structures.
Bishop, Marc D. +3 more
core +2 more sources
Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents
Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar +6 more
wiley +1 more source
Synthesis and Antimicrobial Activity of Some Chalcone Derivatives
In an effort to develop antimicrobial agents, a series of chalcones were prepared by Claisen-Schmidt condensation of appropriate acetophenones with appropriate aromatic aldehydes in the presence of aqueous solution of potassium hydroxide and ethanol at ...
Y. Rajendra Prasad +2 more
doaj +1 more source
Synthesis and chemical properties of 3-acyl- and 3-carbethoxy-4-pyrones [PDF]
Реакция 1-арил-2-диметиламинометиленбутан-1,3-дионов с диэтиоксалатом в присутствии гидрида натрия в ТГФ приводит к образованию этил 5-ароил-4-оксо-4Н-пиран-2- карбоксилатам, из которых 4-оксо-6-арил-4Н-пиран-2-карбоновые кислота (6- арилкомановая ...
Obydennov, D. L. +1 more
core
A Review of Synthesis Methods of Chalcones, Flavonoids, and Coumarins [PDF]
Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids. A three-carbon α, β-unsaturated carbonyl system constitutes chalcones.
Mulugeta, Dinka
core +1 more source
Aiming at the development of antimicrobial agents, we have synthesized nine chlorobenzyl substituted phenothiazinyl chalcones by condensing 2-acetyl phenothiazine with aldehyde derivatives in dilute ethanolic sodium hydroxide solution at room temperature
R. K. Upadhyay +2 more
doaj +1 more source
Liquid Crystal‐Driven Chemical Feeding Accelerates Condensation Reactions in Droplet Microreactors
This work introduces a liquid crystal (LC)‐based platform for dynamic chemical feeding in droplet microreactors, enabling unprecedented control over reaction kinetics and mass transfer. By leveraging LC phase transition‐mediated release, new pathways are unlocked for enhancing confined reaction environments, advancing the fundamental capabilities of ...
Yang Xu +5 more
wiley +1 more source
Anisyl and ferrocenyl adducts of methylenepyran-containing β-diketone: Synthesis, spectral, structural, and redox properties [PDF]
International audienceWittig reaction between the in situ generated [2,6-diphenyl-4H-pyran-4-yl phosphorane and methyl 4-formylbenzoate afforded the methyl 4-[(2,6-diphenyl-4H-pyran-4-ylidene)methyl]benzoate precursor 2 in 75% yield.
Cabon, Nolwenn +7 more
core +3 more sources

