Evaluation of the radical scavenging activity of a series of synthetic hydroxychalcones towards the DPPH radical [PDF]
Journal of the Serbian Chemical Society, 2011 Sixteen hydroxychalcones were synthesized in sufficient purity by the Claisen–Schmidt condensation between appropriate acetophenones and aromatic aldehydes.
STOYAN P. PARUSHEV +3 more
doaj
Stereochemical Studies on a New Ciramadol Analogue by NMR-Spectroscopy [PDF]
, 1994 The absol. configuration of a Ciramadol analogue obtained from (-)-menthone is established by 'H-NMR-. simulated NMR-, COSY-90-, and NOEmeasurements. The final compound 2-(a-1 -pyrrolidino)benzy 1-4-isopropyl- 1 -methyl-cyclohexan-3-one (4b), e.g..
Akgün, H. +4 more
core
Optimized Synthesis of Dinitrochalcones via Ultrasonic Bath in a Cyclohexane–Methanol Solvent System
OrganicsThis study describes the efficient synthesis of five dinitrochalcones (DNCHs) using an ultrasonic bath as an unconventional method to improve reaction yields and reduce reaction times.
Alam Yair Hidalgo +9 more
doaj +1 more source
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells [PDF]
, 2019 With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency.
Evans, David +8 more
core +1 more source
Copper‐Catalyzed Carbonylative Cyclization of CO2: A Promising Approach for Synthesis of Flavone
Advanced Science, Volume 12, Issue 13, April 3, 2025.The study reports the first copper‐catalyzed carbonylative C(sp3)─H bond synthesis of flavone using CO2 as the C1 source. Various aryl iodides and 2‐hydroxyacetophenones tolerated well and transformed into flavone with moderate to good yields. 13C‐labeled flavones are successfully synthesized using [13C]‐CO2, demonstrating significant inhibitor ...
Zijun Huang +7 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 4, April 2025.This study synthesizes and evaluates hybrid cyclotriphosphazene compounds for cancer treatment. The compounds exhibited significant cytotoxicity and genotoxicity against A2780 and Caco‐2 cell lines, inducing DNA damage and apoptosis, with molecular docking suggesting their potential as targeted inhibitors for cancer therapy.
Yunus Yücel +8 more
wiley +1 more source
Molecules, 2012 A series of new chalcones substituted with azide/triazole groups were designed and synthesized, and their cytotoxic activity was evaluated <em>in vitro</em> against the HeLa cell line.
José A. F. P. Villar +8 more
doaj +1 more source
Synthesis and antimicrobial test of heterocyclic chalcone containing oxygen [PDF]
, 2014 Chalcones (1,3-diaryl-2-propen-1-ones) which are belonging to flavanoid family is one of the classes of compounds which possess a wide range of biological activities such as antibacterial, anticancer, antifungal agents and others1.
Jamalis, Joazaizulfazli +2 more
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Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi [PDF]
, 2015 Genomics has revolutionized the research on fungal secondary metabolite (SM) biosynthesis. To elucidate the molecular and enzymatic mechanisms underlying the biosynthesis of a specific SM compound, the important first step is often to find the genes that
Cacho, Ralph A. +2 more
core +1 more source
Synthesis and biological evaluation of new quinoxaline derivatives as antioxidant and anti-inflammatory agents [PDF]
, 2011 We report the synthesis, anti-inflammatory and antioxidant activities of novel quinoxaline and quinoxaline 1,4-di-N-oxide derivatives. Microwave assisted methods have been used in order to optimize reaction times and to improve the yields.
Aldana, I. (Ignacio) +10 more
core +1 more source