Results 111 to 120 of about 768,011 (297)
, 2019 By combining different layers of data, climate services aim at translating state-of-the art climate science to information that can efficiently be incorporated in (urban) planning processes.
de Wit, Rosmarie (5389936) +1 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
, 2019 Worldwide, climate services are emerging as an essential tool to connect the advances in climate science with the domains of climate change adaptation. The modelling methodology developed within the CLARITY project (EU-Horizon 2020, www.clarity-h2020.eu)
Kainz, Astrid +7 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
, 2019 Clarity doctrines are a pervasive feature of legal practice. But there is a fundamental lack of clarity regarding the meaning of legal clarity itself, as critics have pointed out.
Re, Richard
core +1 more source
Measuring Organizational Transparency With 10 Items: Validation of a German Short Scale
Measurement Instruments for the Social SciencesIn recent research on transparency in organizational settings, a multidimensional understanding of supervisor transparency has gained acceptance. Following recent operationalizations, the construct can be measured by the five dimensions of Disclosure ...
C. Richard Hossiep +2 more
doaj +1 more source
CLARITY Demonstration Case Austria - Climate Change Adaptation for the city of Linz
, 2019 The CLARITY methodology, as well as the application of the urban climate model MUKLIMO_3 within the framework of the Austrian Demonstration Case, is presented.
Kainz, Astrid, Kainz, Astrid (6305912)
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Resilient Regions: Clarity of Concepts and Challenges to Systemic Measurement [PDF]
Dealing with perturbations such as economic crises, pandemics and climate change requires an understanding of the resilience and vulnerability of regions.
Yiheyis T Maru
core