Results 111 to 120 of about 2,132,802 (281)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
O "TRACTATUS" DE WITTGENSTEIN COMO UM EDIFÍCIO COM TRAÇOS LOOSIANOS
Princípios, 2014 This article show the Adolf Loos’ ethical crusade against the ornament in architecture, and its influence in the thought of Wittgenstein. First, it shows his attack against the absurdity architectural of Ringstrasse.
José Fernando da Silva
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Topicality of John Paul II’s Pedagogical Message
The Person and the Challenges, 2012 The purpose of this study is to outline the sources and aspects of the time- surpassing topicality of the Pope’s vision of integral education apparent in his anthropological, permeated with faith, reflection on man.
Alina Rynio
doaj +1 more source
A Vote for Clarity: Establishing a Federal Test for Intervention in Election-Related Disputes [PDF]
, 2017 Increasingly, state and federal courts are asked to resolve election-related disputes, as candidates are more likely than ever before to challenge some aspect of the administration of an election in court.
Klein, Ben
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Comparative Legilinguistics, 2019 The aim of this paper is to present LEX.CH.IT, a corpus for micro-diachronic linguistic investigations of Swiss normative acts in Italian. Italian has a peculiar position as an official minority translation language within the Swiss institutional system.
Paolo CANAVESE
doaj +2 more sources
Hunt V. Kenai Peninsula Borough: The Search For Clarity In Legislative Prayer Speaker Selection [PDF]
, 2019 In 2016, three residents of the Kenai Peninsula Borough were prevented from delivering an invocation at a Borough Assembly meeting because they were neither borough chaplains nor members of a qualifying religious association.
Jones, Craig, Truslow, Charles
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source