Results 121 to 130 of about 768,011 (297)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Revista Chilena de Derecho, 2012 El presente ensayo considera la claridad normativa como supuesto básico del Estado de Derecho. La promoción de la claridad normativa requiere, de acuerdo al autor, de la existencia de un sistema de separación institucional de poderes en el cual sean ...
Paul Yowell
doaj
The harmonic centroid as a predictor of string instrument timbral clarity
, 2016 Spectrum is an important factor in determining timbral clarity. An experiment where listeners rate the changes in timbral clarity resulting from spectral equalization (EQ) can provide insight into the relationship between EQ and the clarity of string ...
Hummersone, C., Brookes, T., Hermes, K.
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Experts to provide clarity on medicinal cannabis.
, 2017 An expert group is to devise guidelines to provide clarity for doctors and patients on the safe use of cannabinoid derivatives to treat people with severe epilepsy at a time when debate on its merits is high on the political agenda........
Shanahan, Catherine
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Ignorance et procédures référendaires
Cahiers Droit, Sciences & TechnologiesAlthough the development of methods of citizen participation has demonstrated an increase in citizen competence, referendum processes are still widely criticised for their alleged deliberative deficit, which limits citizens’ understanding of the issues ...
Marthe Fatin-Rouge Stefanini
doaj +1 more source