The Evolution of Class 1 Integrons and the Rise of Antibiotic Resistance [PDF]
Journal of Bacteriology, 2008 ABSTRACT Class 1 integrons are central players in the worldwide problem of antibiotic resistance, because they can capture and express diverse resistance genes. In addition, they are often embedded in promiscuous plasmids and transposons, facilitating their lateral transfer into a wide range of pathogens ...
Michael, Gillings +6 more
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Screening Foodstuffs for Class 1 Integrons and Gene Cassettes [PDF]
Journal of Visualized Experiments, 2015 Antibiotic resistance is one of the greatest threats to health in the 21st century. Acquisition of resistance genes via lateral gene transfer is a major factor in the spread of diverse resistance mechanisms. Amongst the DNA elements facilitating lateral transfer, the class 1 integrons have largely been responsible for spreading antibiotic resistance ...
Liette S, Waldron, Michael R, Gillings
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Costly Class-1 integrons and the domestication of the the functional integrase [PDF]
Mobile Genetic Elements, 2013 Class-1 integrons play an important role in the emergence and spread of antimicrobial resistance determinants. In a recent study we showed that host fitness was dramatically reduced following acquisition of these elements. These fitness costs were due to the presence of an active integrase and we suggested that the mechanistic explanation was due to ...
Harms, Klaus +2 more
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Evolution of class 1 integrons: Mobilization and dispersal via food-borne bacteria. [PDF]
PLoS ONE, 2017 Class 1 integrons have played a major role in the global dissemination of antibiotic resistance. Reconstructing the history of class 1 integrons might help us control further spread of antibiotic resistance by understanding how human activities influence
Timothy M Ghaly +4 more
doaj +1 more source
Carriage of Class 1 integrons and molecular characterization of intI1 gene in multidrug-resistant Salmonella spp. isolates from broilers [PDF]
Veterinary World, 2019 Aim: The present study was conducted with the following aims: (i) To screen the Salmonella spp. isolates recovered from suspected cases of fowl typhoid for carriage of Class 1 integrons and analyze their association with antimicrobial resistance and (ii)
Renu Gupta +5 more
doaj +1 more source
Loop-mediated isothermal amplification assays for screening of bacterial integrons
Biological Research, 2014 BACKGROUND: The occurrence and prevalence of integrons in clinical microorganisms and their role played in antimicrobial resistance have been well studied recently.
Guangchao Yu +9 more
doaj +1 more source
First observation of excision and integration in Class 1 integron in staphylococci [PDF]
, 2013 Class 1 integron had been well-known as a mobile genetic element involved in the antibiotic resistance of various bacteria. Up to date, most of the relevant publications concentrated on gram-negative bacteria, with limited exceptions.
Chu, J +7 more
core +1 more source
Bioinformatic analysis of multi-drug resistant class 1 integron-coded protein of Citrobacter freundii [PDF]
, 2021 Background: The understanding of the secondary structure of the class 1 integron coded protein is necessary to decipher potential drug target and also to infer evolutionary ancestry at the proteomic level.
Popoola, O.D. +3 more
core +1 more source
“Distribution and functional identification of complex class 1 integrons”
Infection, Genetics and Evolution, 2013 The emergence of extended-spectrum β-lactamases and plasmid-mediated resistance to quinolones has been previously found to be associated with the dissemination of complex class 1 integrons in Argentina. In this study, we analyzed their distribution through time and evaluated the functionality of the Orf513 protein, which is the putative recombinase of ...
Quiroga, María Paula +7 more
openaire +3 more sources
Tn5090-like class 1 integron carrying blaVIM-2 in a Pseudomonas putida strain from Portugal [PDF]
, 2010 Three Pseudomonas putida strains containing blaVIM-2 were isolated from an inanimate surface of a female ward sanitary facility in the Hospital Infante D. Pedro, Aveiro. A novel class 1 integron was found in strain Pp2 (aacA41blaVIM-2/aac6'-IIc disrupted
Santos, C. +3 more
core +2 more sources