Results 31 to 40 of about 3,946 (256)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground This study examined the longitudinal associations of psychosocial stress subgroups with cardiovascular disease (CVD) events and whether social support, neighborhood cohesion, and physical activity modified these associations in MESA (Multi ...
Tiwaloluwa A. Ajibewa +5 more
doaj +1 more source
Land, 2018 Context: The fundamental driving force of land use and land cover (LULC) change is related to spatial and temporal processes caused by human activities such as agricultural expansion and demographic change. Landscape metrics were used to analyze post-war
Rahel Hamad, Kamal Kolo, Heiko Balzter
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
GeographiesThis study aims to investigate the short-term dynamics of agricultural landscapes using AI-supported multi-temporal land use/land cover (LULC) data. The Finike district, located within the Mediterranean climate zone, was selected as the study area, and ...
Nihat Karakuş +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Security metrics for object-oriented class designs
, 2009 Measuring quality attributes of object-oriented\ud designs (e.g. maintainability and performance) has\ud been covered by a number of studies. However, these\ud studies have not considered security as much as other\ud quality attributes.
Corney, Diane +5 more
core +1 more source
Designing and implementing a tool for measuring cohesion and coupling of Object-Oriented Systems
, 2022 Cohesion and coupling are considered essential elements of an object-oriented system\u27s internal quality. The class diagram represents an important part of the design phase of the development life cycle of the software.
Atica M. Altaie
core +1 more source
On the effectiveness of multi-scale landscape metrics in soil organic carbon mapping
GeodermaSoil organic carbon (SOC) mapping delivers invaluable information to the global carbon budget and climate change mitigation endeavour. Environmental variables at sample locations are frequently used as explanatory variables for simulating the spatial ...
Jiaxue Wang +7 more
doaj +1 more source