Results 41 to 50 of about 3,946 (256)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

High Precision Cohesion Metric [PDF]

, 2020
: -Metrics have been used to measure many attributes of software. For object oriented software, cohesion indicates the level of binding of the class elements. A class with high cohesion is one of the desirable properties of a good object oriented design.
R V Uthariaraj, N Kayarvizhy, S Kanmani
core  

An experimental search-based approach to cohesion metric evaluation [PDF]

, 2016
In spite of several decades of software metrics research and practice, there is little understanding of how software metrics relate to one another, nor is there any established methodology for comparing them.
Laurence Tratt, Hemati Moghadam, I, O'Cinneide, M, Hemati Moghadam, Iman, Moghadam, IH, Counsell, S, Steven Counsell (12616210), Mel Ó Cinnéide, Mark Harman, Tratt, L, Harman, Mark, Iman Hemati Moghadam, Steve Counsell, Harman, M, Ó Cinnéide, Mel, Mel Ó Cinnéide (12618964), Ó Cinnéide, M, Laurence Tratt (12620293), Tratt, Laurence, Mark Harman (5293477), Counsell, Steve, Iman Hemati-Moghadam (12619600)   +21 more
core   +1 more source

A Criterion-Driven Consistency Indicator for Evaluating Multicriteria Sorting and Clustering Results

Mathematics
This study investigates the role of data structure in multicriteria sorting by integrating supervised and unsupervised approaches. Specifically, a hybrid framework combining TOPSIS-Sort-B and cluster analysis is proposed to define class boundaries and ...
Maiquiel Schmidt de Oliveira, Flavio Trojan, Vilmar Steffen, Maressa Fontana Mezoni   +3 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Exploring the eradication of code smells: An empirical and theoretical perspective [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2010 Hindawi Publishing CorporationCode smells reflect code decay, and, as such, developers should seek to eradicate such smells through application of ...
H. Hamza, Durrand, M, M. Durrand, S. Black, Black, S, Counsell, S, Hierons, RM, Hamza, H, R. M. Hierons, S. Counsell   +9 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Identifying Clusters of Concepts in a Low Cohesive Class for Extract Class Refactoring Using Metrics Supplemented Agglomerative Clustering Technique

CoRR, 2012
10 pages, 8 figures, 4 tables; ISSN (Online): 1694 ...
A. Ananda Rao, K. Narendar Reddy
openaire   +2 more sources

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Cohesion Metrics for Improving Software Quality [PDF]

, 2016
Software product metrics aim at measuring the quality of software. Modu- larity is an essential factor in software quality. In this work, metrics related to modularity and especially cohesion of the modules, are considered.
Mäkelä, Sami
core