Results 71 to 80 of about 268,103 (267)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mirroring in lattice equations and a related functional equation

Electronic Journal of Qualitative Theory of Differential Equations
We use a functional form of the mirroring technique to fully characterize equivalence classes of unbounded stationary solutions of lattice reaction-diffusion equations with eventually negative and decreasing nonlinearities.
Jakub Hesoun, Petr Stehlík, Jonas Volek
doaj   +1 more source

On a Class of Functional Equations in Distribution

Journal of Mathematical Analysis and Applications, 1998
The most general solutions of the functional equations arising in connection with the characterization of sum form information measures, \[ f(xy)+ f(x(1-y))+ f(y(1-x))+ f((1-x)(1-y))= f(x)+ f(1-x)+ f(y)+ f(1-y), \] and \[ f(xy)+ f((1-x)(1-y))= f(x(1-y))+ f(y(1-x)), \] are obtained in the domain of distributions.
Deeba, Elias, Sahoo, P.K, Xie, Shishen
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Continuity Equation of Transverse Kähler Metrics on Sasakian Manifolds

Mathematics
We introduce the continuity equation of transverse Kähler metrics on Sasakian manifolds and establish its interval of maximal existence. When the first basic Chern class is null (resp. negative), we prove that the solution of the (resp.
Yushuang Fan, Tao Zheng
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Hyers-Ulam Stability of Iterative Equation in the Class of Lipschitz Functions

Discrete Dynamics in Nature and Society, 2014
Hyers-Ulam stability is a basic sense of stability for functional equations. In the present paper we discuss the Hyers-Ulam stability of a kind of iterative equations in the class of Lipschitz functions.
Chao Xia, Wei Song
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

ON A CLASS OF SINGULAR INTEGRAL EQUATIONS

Demonstratio Mathematica, 1995
The properties and applications of an operator \(C\) in \(L^{p,\alpha,\beta} (\mathbb{R}_+)\) (a weighted Lebesgue space of functions \(p\)-summable on \(\mathbb{R}_+)\) to be determined by the integral equations of a certain class are discussed.
openaire   +2 more sources