Results 91 to 100 of about 4,227,419 (291)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Are We All ‘BBC Dad’ Now? What Covid-19 Restrictions Reveal About Comedy, Class, Paid Work, Parenting and Gender [PDF]
, 2021 The meme ‘BBC Dad’ first emerged in 2017 in response to an ‘embarrassing’ moment where a Professor was interrupted by his family during a live interview with BBC news TV.
Giuffre E
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Solutions for the Cahn-Hilliard Equation With Many Boundary Spike Layers [PDF]
, 2001 In this paper we construct new classes of stationary solutions for the Cahn-Hilliard equation by a novel approach. One of the results is as follows: Given a positive integer K and a (not necessarily nondegenerate) local minimum point of the mean
Winter, M, Wei, J
core +1 more source
Continuity Equation of Transverse Kähler Metrics on Sasakian Manifolds
MathematicsWe introduce the continuity equation of transverse Kähler metrics on Sasakian manifolds and establish its interval of maximal existence. When the first basic Chern class is null (resp. negative), we prove that the solution of the (resp.
Yushuang Fan, Tao Zheng
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A BPE model for the Burgers' equation [PDF]
We study the BPE (Brownian particle equation) model of the Burgers equation presented in the preceeding article [6]. More precisely, we are interested in establishing the existence and uniqueness properties of solutions using probabilistic techniques ...
Arturo Kohatsu, Shigeyoshi Ogawa
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Hyers-Ulam Stability of Iterative Equation in the Class of Lipschitz Functions
Discrete Dynamics in Nature and Society, 2014 Hyers-Ulam stability is a basic sense of stability for functional equations. In the present paper we discuss the Hyers-Ulam stability of a kind of iterative equations in the class of Lipschitz functions.
Chao Xia, Wei Song
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Quantile regression methods for recursive structural equation models [PDF]
Two classes of quantile regression estimation methods for the recursive structural equation models of Chesher (2003) are investigated. A class of weighted average derivative estimators based directly on the identification strategy of Chesher is ...
Roger Koenker, Lingjie Ma
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