Results 101 to 110 of about 4,227,419 (291)

Existence of periodic solutions for a class of functional integral equation

Electronic Journal of Qualitative Theory of Differential Equations, 2012
In this paper, we investigate the existence of periodic solution for a class of nonlinear functional integral equation. We first prove a fixed point theorem in a Banach algebra and with its help, an existence theorem about periodic solution to the ...
Wei Long, Xiong-Jun Zheng, Lu Li
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The p-Laplace equation in a class of Hormander vector fields

Electronic Journal of Differential Equations, 2019
We find the fundamental solution to the p-Laplace equation in a class of Hormander vector fields that generate neither a Carnot group nor a Grushin-type space. The singularity occurs at the sub-Riemannian points, which naturally corresponds to finding
Thomas Bieske, Robert D. Freeman
doaj  

Integration of the Loaded Negative Order Nonlinear Schrodinger Equation in the Class of Periodic Functions

Известия Иркутского государственного университета: Серия "Математика"
In this paper, we consider the loaded negative order nonlinear Schrodinger equation (NSE) in the class of periodic functions. It is shown that the loaded negative order nonlinear Schrodinger equation can be integrated by the inverse spectral problem ...
M. M. Khasanov, I. D. Rakhimov, D. B. Azimov   +2 more
doaj   +1 more source

On Continual Classes of Evolution Equations

, 2005
The original Miura transformation, considered as a nonlinear potential transformation, is applicable to a continual class of evolution equations, not only to discrete integrable equations and their hierarchies. The same continual class of evolution equations appears from a different problem, namely, from the gauge-invariant description of a zero ...
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ground-State Solutions for a Class of N-Laplacian Equation with Critical Growth

Abstract and Applied Analysis, 2012
We investigate the existence of ground-state solutions for a class of N-Laplacian equation with critical growth in ℝN. Our proof is based on a suitable Trudinger-Moser inequality, Pohozaev-Pucci-Serrin identity manifold, and mountain pass lemma.
Guoqing Zhang, Jing Sun
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Existence of Prescribed L2-Norm Solutions for a Class of Schrödinger-Poisson Equation

Abstract and Applied Analysis, 2013
By using the standard scaling arguments, we show that the infimum of the following minimization problem: Iρ2=inf{(1/2)∫ℝ3|∇u|2dx+(1/4)∬ℝ3(|u(x)|2|u(y)|2/|x-y|)dx dy −  (1/p)∫ℝ3|u|pdx:u∈Bρ} can be achieved for p∈(2,3) and ρ>0 small, where Bρ:={u∈H1(ℝ3):∥u∥
Yisheng Huang, Zeng Liu, Yuanze Wu
doaj   +1 more source