Results 81 to 90 of about 2,012,091 (336)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Electronic Journal of Qualitative Theory of Differential Equations, 2017 The paper is devoted to the study of the solvability of a nonlinear Volterra–Stieltjes integral equation in the class of real functions defined, bounded and continuous on the real half-axis $\mathbb{R}_+$ and having finite limits at infinity.
Jozef Banas, Agnieszka Dubiel
doaj +1 more source
Lifespan of solutions for a class of pseudo-parabolic equation with weak-memory
Alexandria Engineering Journal, 2020 The most important feature in this article is the existence of the weak-viscoelastic terms which can’t pull out the whole system. It is concerned mainly with the global in time non-existence for a large class of pseudo-parabolic equation with weak ...
Khaled Zennir, Tosiya Miyasita
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Social class and gender in an equation of students' mathematics identity [PDF]
Nastava i VaspitanjeAddressing the achievement gap in mathematics across social class and gender is essential, as mathematics is widely seen as a pathway to social mobility and a tool for breaking cycles of inequality.
Mićić Katarina, Jovanović Olja
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Numerical Solution for a Class of Evolution Differential Equations with $p$-Laplacian and Memory [PDF]
, 2022 Rui M.P. Almeida +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source