Results 81 to 90 of about 268,103 (267)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The p-Laplace equation in a class of Hormander vector fields

Electronic Journal of Differential Equations, 2019
We find the fundamental solution to the p-Laplace equation in a class of Hormander vector fields that generate neither a Carnot group nor a Grushin-type space. The singularity occurs at the sub-Riemannian points, which naturally corresponds to finding
Thomas Bieske, Robert D. Freeman
doaj  

Integration of the Loaded Negative Order Nonlinear Schrodinger Equation in the Class of Periodic Functions

Известия Иркутского государственного университета: Серия "Математика"
In this paper, we consider the loaded negative order nonlinear Schrodinger equation (NSE) in the class of periodic functions. It is shown that the loaded negative order nonlinear Schrodinger equation can be integrated by the inverse spectral problem ...
M. M. Khasanov, I. D. Rakhimov, D. B. Azimov   +2 more
doaj   +1 more source

Ground-State Solutions for a Class of N-Laplacian Equation with Critical Growth

Abstract and Applied Analysis, 2012
We investigate the existence of ground-state solutions for a class of N-Laplacian equation with critical growth in ℝN. Our proof is based on a suitable Trudinger-Moser inequality, Pohozaev-Pucci-Serrin identity manifold, and mountain pass lemma.
Guoqing Zhang, Jing Sun
doaj   +1 more source

Existence of periodic solutions for a class of functional integral equation

Electronic Journal of Qualitative Theory of Differential Equations, 2012
In this paper, we investigate the existence of periodic solution for a class of nonlinear functional integral equation. We first prove a fixed point theorem in a Banach algebra and with its help, an existence theorem about periodic solution to the ...
Wei Long, Xiong-Jun Zheng, Lu Li
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Existence of Prescribed L2-Norm Solutions for a Class of Schrödinger-Poisson Equation

Abstract and Applied Analysis, 2013
By using the standard scaling arguments, we show that the infimum of the following minimization problem: Iρ2=inf{(1/2)∫ℝ3|∇u|2dx+(1/4)∬ℝ3(|u(x)|2|u(y)|2/|x-y|)dx dy −  (1/p)∫ℝ3|u|pdx:u∈Bρ} can be achieved for p∈(2,3) and ρ>0 small, where Bρ:={u∈H1(ℝ3):∥u∥
Yisheng Huang, Zeng Liu, Yuanze Wu
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source