Results 101 to 110 of about 14,390,534 (297)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Advanced Concepts in Particle and Field Theory [PDF]
, 2016 Uniting the usually distinct areas of particle physics and quantum field theory, gravity and general relativity, this expansive and comprehensive textbook of fundamental and theoretical physics describes the quest to consolidate the elementary particles ...
Hübsch, Tristan
core +1 more source
String field theory as world-sheet UV regulator
Journal of High Energy Physics, 2019 Even at tree level, the first quantized string theory suffers from apparent short distance singularities associated with collision of vertex operators that prevent us from straightforward numerical computation of various quantities.
Ashoke Sen
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Anomaly Cancelation in Field Theory and F-theory on a Circle [PDF]
, 2016 We study the manifestation of local gauge anomalies of four- and six-dimensional field theories in the lower-dimensional Kaluza-Klein theory obtained after circle compactification. We identify a convenient set of transformations acting on the whole tower
Sub String Theory Cosmology and ElemPart +5 more
core +1 more source
Erratum to: Cutkosky rules for superstring field theory
Journal of High Energy Physics, 2018 Superstring field theory expresses the perturbative S-matrix of superstring theory as a sum of Feynman diagrams each of which is manifestly free from ultraviolet divergences.
Roji Pius, Ashoke Sen
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
IDÈLIC CLASS FIELD THEORY FOR 3-MANIFOLDS
, 2014 Following the analogies between three-dimensional topology and number theory, we study an idèlic form of class field theory for 3-manifolds. For a certain set K of knots in a 3-manifold M, we first present a local theory for each knot in K, which is ...
Niibo, Hirofumi
core
Higgs mechanism in nonlocal field theories
Journal of High Energy Physics, 2018 We study spontaneous gauge symmetry breaking and the Higgs mechanism in nonlocal field theories. Motivated by the level truncated action of string field theory, we consider a class of nonlocal field theories with an exponential factor of the d ...
Manami Noumi Hashi +4 more
doaj +1 more source