Results 171 to 180 of about 1,645,348 (266)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Systematic Evaluation of Peptidomimetic Modifications in a Major Histocompatibility Complex Class I Model Epitope: A Framework for Immunogenic Antigen Design. [PDF]

ACS Chem Biol
Newkirk SE, Kelly JJ, Hourn N, Bhandari S, Spencer N, Pires MM.   +5 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Killip Class I [PDF]

, 2020
openaire   +1 more source

Expanded Allelic Diversity of Non-Classical HLA Class I and MIC Loci Identified Using Full-Gene Hybrid Capture-Based Next-Generation Sequencing. [PDF]

HLA
Chaaithanya IK, Raghav PK, Lee N, Wirtz C, Kong D, Rajalingam R.   +5 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

HLA class-I genotyping to personalize Bacille Calmette-Guerin immunotherapy in bladder cancer. [PDF]

Oncoimmunology
Ruiz-Lorente I, Gimeno L, López-Abad A, Cubillana PL, Aparicio TF, Egea LJA, Avilés JM, Iñiguez GD, Martínez-Valls PLG, Server G, Ferri B, Campillo JA, Galindo F, Martínez-Sánchez MV, Minguela A.   +14 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Mapping HLA class I and II allele associations with hepatitis C related liver disease progression in an Egyptian cohort. [PDF]

Discov Oncol
M Lotfy M, Ebrahim NAA, El-Kassas M, Omar Abdel-Aziz A, Abdelhamid Omran D, Abdelfatah D, Barakat AB, Salah El-Din Youssef A, Nassar A, K Soliman H, N Zekri AR.   +10 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source