Results 211 to 220 of about 20,214,462 (360)

Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I. [PDF]

Discov Immunol
Murali TM, Li B, Hoos E, Collinson L, Long EO, Dushek O, Elliott T, Sim MJW.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells. [PDF]

Bioconjug Chem
Sneddon MS, Tsou CJ, Fu X, Shelat AA, Pomerantz WCK.   +4 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Messing with Signal 1: How Perturbed MHC Class I Antigen Presentation Contributes to Cancer. [PDF]

Cells
Lawand M, Al Rayess S, Jaber R, van Endert P.   +3 more
europepmc   +1 more source

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

Science, 2016
Juliane Liepe, F. Marino, J. Sidney, Anita Jekő, Daniel C. E. Bunting, A. Sette, P. Kloetzel, M. Stumpf, A. Heck, M. Mishto   +9 more
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Zapnometinib treatment and influenza A virus infection modulate the HLA class I ligandome in human lung adenocarcinoma cells. [PDF]

Front Immunol
Hamza H, Ghosh M, Rammensee HG, Planz O.
europepmc   +1 more source

NLRC5/MHC class I transactivator is a target for immune evasion in cancer

Proceedings of the National Academy of Sciences of the United States of America, 2016
S. Yoshihama, J. Roszik, Isaac Downs, T. Meissner, Saptha Vijayan, B. Chapuy, Tabasum Sidiq, M. Shipp, G. Lizée, Koichi S. Kobayashi   +9 more
semanticscholar   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source