Results 21 to 30 of about 20,214,462 (360)

Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)

Pharmaceuticals, 2022
Compounds that contain (R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid substituted with bicyclic amino moiety (2-aza-bicyclo[2.2.1]heptane) were designed using molecular modelling methods, synthesised, and found to be potent DPP-4 (dipeptidyl ...
Ivan O. Maslov, Tatiana V. Zinevich, Olga G. Kirichenko, Mikhail V. Trukhan, Sergey V. Shorshnev, Natalya O. Tuaeva, Maxim A. Gureev, Amelia D. Dahlén, Yuri B. Porozov, Helgi B. Schiöth, Vladimir M. Trukhan   +10 more
doaj   +1 more source

Down-regulation of MHC class I is a property common to papillomavirus E5 proteins [PDF]

, 2006
The E5 protein family of papillomaviruses comprises small hydrophobic proteins which are associated with the cell endomembrane compartments. The functions of the E5 proteins, particularly those of HPV, are still far from clear.
Fife, K.H., G.H. Ashrafi, Ashrafi, G, Campo, M, D.R. Brown, Ashrafi, G.H., M.S. Campo, Brown, D.R., Fife, K, Campo, M.S., Brown, D R, K.H. Fife   +11 more
core   +1 more source

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Marchetti, B, Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B., Araibi, E. H.   +5 more
core   +1 more source

A large peptidome dataset improves HLA class I epitope prediction across most of the human population

Nature Biotechnology, 2019
Prediction of HLA epitopes is important for the development of cancer immunotherapies and vaccines. However, current prediction algorithms have limited predictive power, in part because they were not trained on high-quality epitope datasets covering a ...
Siranush Sarkizova, Susan Klaeger, Phuong M. Le, Letitia W. Li, G. Oliveira, Hasmik Keshishian, Christina R. Hartigan, Wandi Zhang, D. Braun, K. Ligon, P. Bachireddy, I. Zervantonakis, Jennifer M. Rosenbluth, Tamara Ouspenskaia, T. Law, S. Justesen, Jonathan D. Stevens, W. Lane, T. Eisenhaure, Guang Lan Zhang, K. Clauser, N. Hacohen, S. Carr, Catherine J. Wu, D. Keskin   +24 more
semanticscholar   +1 more source

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by D94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis [PDF]

, 1998
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I ...
John E. Coligan, Matthias Ulbrecht, Ulbrecht, Matthias, Coligan, John E., Andrew G. Brooks, Brooks, AG, Borrego, F, Coligan, JE, Elisabeth H. Weiss, Brooks, Andrew G., Francisco Borrego, Borrego, Francisco, Weiss, Elisabeth H., Ulbrecht, M, Weiss, EH   +14 more
core   +1 more source

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Cancer Cell, 2019
Summary Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates ...
M. Burr, C. Sparbier, K. Chan, Yih-Chih Chan, A. Kersbergen, E. Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C. Bell, O. Gilan, Susan Jackson, L. Tan, S. Wong, Sebastian Hollizeck, Ewa M Michalak, H. Siddle, M. McCabe, R. Prinjha, Glen R Guerra, B. Solomon, S. Sandhu, S. Dawson, P. Beavis, R. Tothill, C. Cullinane, P. Lehner, K. Sutherland, M. Dawson   +27 more
semanticscholar   +1 more source

NetMHCpan 4.0: Improved peptide-MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data

Journal of Immunology, 2017
Cytotoxic T cells are of central importance in the immune system’s response to disease. They recognize defective cells by binding to peptides presented on the cell surface by MHC class I molecules.
V. Jurtz, S. Paul, M. Andreatta, P. Marcatili, Bjoern Peters, M. Nielsen   +5 more
semanticscholar   +1 more source

On the class of QS‐algebras [PDF]

International Journal of Mathematics and Mathematical Sciences, 2004
We consider some fundamental properties of QS‐algebras and show that (1) the theory of QS‐algebras is logically equivalent to the theory of Abelian groups, that is, each theorem of QS‐algebras is provable in the theory of Abelian groups, and conversely, each theorem of Abelian groups is provable in the theory of QS‐algebras; and (2) a G‐part G(X) of a ...
openaire   +2 more sources

A Physical Map Including a New Class I Gene (cda12) of the Human Major Histocompatibility Complex (A2/313 Haplotype) Derived from a Monosomy 6 Mutant Cell Line [PDF]

, 1989
To avoid interpretative problems due to restriction fragment length polymorphisms, the monosomy 6 mutant cell line BM19.7 was employed to establish a molecular map of the human major histocompatibility (HLA) complex in the A2,B13,Bw4,DRw6,DRw52,DQw1,DPw2
Pohla, Heike, Bloemer, K, Messer, Gerald, Bloemer, Katharina, Messer, G, Ziegler, Andreas, Ragoussis, Jiannis, Ragoussis, J, Weiss, Elisabeth H., Pohla, H, Weiss, EH, Ziegler, A   +11 more
core   +1 more source