Results 41 to 50 of about 20,214,462 (360)

Molecular analysis of various classes of integrons in the clinical Pseudomonas aeruginosa isolates by Multiplex-PCR [PDF]

Journal of Advanced Biomedical Sciences, 2017
Background & Objective: The presence of classes I, II and III Integrons in multidrug-resistant Pseudomonas aeruginosa strains, has created new concerns in clinics. This study aimed to investigate the prevalence of class I, II and III Integron in clinical
Atousa Rashidi, Gholamali Moradli
doaj  

Assessing Teacher Digital Competence: the Construction of an Instrument for Measuring the Knowledge of Pre-Service Teachers

Journal of New Approaches in Educational Research, 2019
Assessing competences always poses a challenge and can be even more complicated when tackling a multidimensional competence like teacher digital competence (TDC). TDC is understood to consist of different dimensions linked to its components.
José Luis Lázaro-Cantabrana, Mireia Usart-Rodríguez, Mercè Gisbert-Cervera   +2 more
doaj   +1 more source

Double Proteolysis for N- and O-glycan Analysis of Fc-fusion Protein Etanercept

Разработка и регистрация лекарственных средств, 2023
Introduction. Highly glycosylated proteins are the most abundant class of modern biopharmaceuticals. A majority of such therapeuticals produced by Russian biopharmaceutical companies is biosimilars.
V. G. Varzieva, N. V. Mesonzhnik, A. О. Belushenko, N. L. Bochkareva, S. А. Appolonova   +4 more
doaj   +1 more source

A peptide filtering relation quantifies MHC class I peptide optimization

, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Luca Cardelli, Goldstein, LD, Phillips, Andrew, Emmott, Stephen, Elliott, T, Mark Howarth, Werner, JM, Werner, Joern M., Leonard D. Goldstein, Andrew Phillips, Elliot, Tim, Dalchau, Neil, Goldstein, Leonard D., Cardelli, L, Cardelli, Luca, Tim Elliott, Dalchau, N, Emmott, S, Neil Dalchau, Howarth, M, Elliott, Tim, Leonard D Goldstein, Joern M. Werner, Phillips, A, Joern M Werner, Stephen Emmott, Howarth, Mark   +26 more
core   +1 more source

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Cancer Discovery, 2017
Mechanisms of acquired resistance to immune checkpoint inhibitors (ICIs) are poorly understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate whether alterations in genes encoding HLA Class I antigen processing and ...
S. Gettinger, Jungmin Choi, K. Hastings, A. Truini, I. Datar, R. Sowell, A. Wurtz, W. Dong, G. Cai, Mary Ann Melnick, Victor Y. Du, J. Schlessinger, S. Goldberg, A. Chiang, M. Sanmamed, I. Melero, J. Agorreta, L. Montuenga, R. Lifton, S. Ferrone, P. Kavathas, D. Rimm, S. Kaech, K. Schalper, R. Herbst, K. Politi   +25 more
semanticscholar   +1 more source

Survey and Detection of Pectobacterium atrosepticum in Major Potato-Growing Areas in Central Java Province, Indonesia

Ilmu Pertanian (Agricultural Science), 2017
Potato (Solanum tuberosum) is a seasonal shrub-tuber crop originated from sub-tropical area. Soft-rot is one of the most important diseases of potato. It can be caused by Pectobactorium atrosepticum, a pathogen within a status of quarantine plant pest A1
Ismiyatuningsih Ismiyatuningsih, Tri Joko, Sedyo Hartono   +2 more
doaj   +1 more source

Class I polytropes for anisotropic matter

European Physical Journal C: Particles and Fields, 2021
In this work we study class I interior solutions supported by anisotropic polytropes. The generalized Lane–Emden equation compatible with the embedding condition is obtained and solved for a different set of parameters in both the isothermal and non ...
A. Ramos, C. Arias, E. Fuenmayor, E. Contreras   +3 more
doaj   +1 more source

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment [PDF]

, 1992
Selective expression of murine cytomegalovirus (MCMV) immediate-early (IE) genes leads to the presentation by the major histocompatibility complex (MHC) class I molecule L a of a peptide derived from MCMV IE protein pp89 (Reddehase, M. J., J.
Koszinowski, Ulrich H., Hartlaub, Udo, T Ruppert, U H Koszinowski, H Hengel, Del Val, Margarita, Lucin, Pero, U Hartlaub, M del Val, P Lucin, Häcker, Hans, Ruppert, Thomas, H Häcker, Hengel, Hartmut   +13 more
core   +1 more source

E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domai [PDF]

, 2006
Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I;
Marchetti, Barbara, Ashrafi, G. Hossein, Haghshenas, Mohammad, Ashrafi, G.H., Haghshenas, M., Campo, M.S., Marchetti, B., Campo, M. Saveria   +7 more
core   +1 more source

High-throughput prediction of MHC class I and class II neoantigens with MHCnuggets

Cancer immunology research, 2019
An in silico predictor of peptide ligands that can bind to major histocompatibility complex (MHC) proteins is developed and used to assess potential neoantigens and immunogenic missense mutations (IMMs) in 6,613 TCGA patients. Computational prediction of
X. Shao, R. Bhattacharya, Justin C. Huang, I. Sivakumar, Collin J Tokheim, Lily Zheng, Lily Zheng, Dylan Hirsch, Benjamin Kaminow, Ashton R. Omdahl, M. Bonsack, M. Bonsack, A. Riemer, V. Velculescu, V. Velculescu, V. Anagnostou, K. Pagel, R. Karchin   +17 more
semanticscholar   +1 more source