Results 1 to 10 of about 38,654,738 (261)

Progress on quinoline‑based antitumour agents: Mechanistic insights and optimization strategies (Review). [PDF]

Mol Med Rep
Zeng Y, Yan Y, Wu S, Wu W, Chen K, Lai Y, Ye Q, Zhang N, Zhou Y.   +8 more
europepmc   +1 more source

KLF15-POU3F4 axis activates PI3K/AKT signaling to promote glioma progression. [PDF]

Transl Cancer Res
Wang D, Yu W, Wang R, Liu N.
europepmc   +1 more source

Does the ERBB/EGF Signaling Network Serve as a Nexus for Oncogenic Signals in Uveal Melanoma? [PDF]

Biomolecules
Raeesian N, Riese DJ.
europepmc   +1 more source

The multifaceted significance of phosphoinositides in endocytic trafficking. [PDF]

FEBS Lett
Xie C, Shi A.
europepmc   +1 more source

Novel therapeutic targets at the crossroad between epigenetics and signal transduction pathways in B-cell lymphomas. [PDF]

Clin Exp Med
Uddin Dekha J, Yami A, Quotti Tubi L, Haxhiu I, Carrer A, Trentin L, Piazza F, Manni S.   +7 more
europepmc   +1 more source

Structures of the PI3Kα/KRas complex on lipid bilayers reveal molecular mechanisms of PI3Kα activation. [PDF]

Mol Cell
Torosyan H, Paul MD, Meyer BG, Maker A, Jura N, Verba KA.   +5 more
europepmc   +1 more source

(Phospho)proteomic Profiling Reveals Mutation-Specific Adaptive Signaling to PI3Kα Inhibition in <i>PIK3CA</i> Mutant Breast Epithelial Cells. [PDF]

J Proteome Res
Wang F, Altelaar M, Stecker KE.
europepmc   +1 more source

Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms [PDF]

Molecules, 2011
Class I PI3 Kinase (PI3K) phosphorylates phosphatidylinositol 4,5-bisphophate (PIP2) to generate the second messenger phosphatidylinositol 3,4,5-trisphosphate (PIP3) and therefore plays an important role in fundamental cellular responses such as proliferation.
Meihua Jin, Dexin Kong, Takao Yamori
exaly   +4 more sources

Phosphatidylinositol—and related-kinases: A genome-wide survey of classes and subtypes in the genome for designing subtype-specific inhibitors

Biochemical and Biophysical Research Communications, 2009
Luciana Márcia Oliveira, Renato A Mortara, Diana Bahia   +2 more
exaly  

Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

FEBS Letters, 2012
Harald W Platta, Harald Stenmark
exaly