Results 11 to 20 of about 38,654,738 (261)

Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy

Acta Pharmaceutica Sinica B, 2017
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers. Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,
Wennan Zhao, Yuling Qiu, Dexin Kong
doaj   +6 more sources

Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer [PDF]

Frontiers in Systems Biology
IntroductionSMG1, a phosphatidylinositol 3-kinase-related kinase (PIKK) family serine/threonine kinase, is a key regulator of nonsense-mediated mRNA decay (NMD) through phosphorylation of UPF1 and plays important roles in genome stability, p53 activation,
Apoorva K. A. Pai, Leona Dcunha, Athira Perunelly Gopalakrishnan, Samseera Ummar, Athira C. Rajeev, Rajesh Raju   +5 more
doaj   +2 more sources

Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. [PDF]

PLoS Pathogens, 2006
The causative agent of Legionnaires' disease, Legionella pneumophila, employs the intracellular multiplication (Icm)/defective organelle trafficking (Dot) type IV secretion system (T4SS) to upregulate phagocytosis and to establish a replicative vacuole ...
Stefan S Weber, Curdin Ragaz, Katrin Reus, Yves Nyfeler, Hubert Hilbi   +4 more
doaj   +2 more sources

Somatic mutation analysis of Mesonephric-Like adenocarcinoma and associated putative precursor Lesions: Insight into pathogenesis and potential molecular treatment targets

Gynecologic Oncology Reports, 2022
Aims: Mesonephric-like adenocarcinoma (MLA) is a recently described histologic tumor subtype of the Müllerian tract. MLA can arise in association with Müllerian lesions that share common mutations.
Elizabeth Arslanian, Kamaljeet Singh, C. James Sung, M. Ruhul Quddus   +3 more
doaj   +1 more source

Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases. [PDF]

Am J Respir Cell Mol Biol, 2012
The ADP-ribosyl cyclase activity of CD38 generates cyclic ADP-ribose, a Ca(2+)-mobilizing agent. In human airway smooth muscle (HASM) cells, TNF-α mediates CD38 expression through mitogen-activated protein kinases and NF-κB and AP-1. The phosphatidylinositol-3 kinase/Akt (PI3K/Akt) pathway is involved in TNF-α signaling and contributes to airway ...
Jude JA, Tirumurugaan KG, Kang BN, Panettieri RA, Walseth TF, Kannan MS.   +5 more
europepmc   +3 more sources

The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation [PDF]

The Journal of Immunology, 2021
Abstract The PI3K pathway plays a key role in B cell activation and is important for the differentiation of Ab producing plasma cells (PCs). Although much is known about the molecular mechanisms that modulate PI3K signaling in B cells, the transcriptional regulation of PI3K expression is poorly understood.
Bin Xie, Tariq E Khoyratty, Enas Abu-Shah, Pablo F Cespedes, Andrew J MacLean, Gabriela Pirgova, Zhiyuan Hu, Ahmed A Ahmed, Michael L Dustin, Irina A Udalova, Tal I Arnon   +10 more
openaire   +3 more sources

Phosphatidylinositol kinases in GtoPdb v.2021.3 [PDF]

, 2021
Phosphatidylinositol may be phosphorylated at either 3- or 4- positions on the inositol ring by PI 3-kinases or PI 4-kinases, respectively.Phosphatidylinositol 3-kinasesPhosphatidylinositol 3-kinases (PI3K, provisional nomenclature) catalyse the ...
Uddin, Mohib
core   +1 more source

Phosphatidylinositol kinases in GtoPdb v.2023.1 [PDF]

, 2023
Phosphatidylinositol may be phosphorylated at either 3- or 4- positions on the inositol ring by PI 3-kinases or PI 4-kinases, respectively.Phosphatidylinositol 3-kinasesPhosphatidylinositol 3-kinases (PI3K, provisional nomenclature) catalyse the ...
Uddin, Mohib, Mohib Uddin
core   +1 more source

Class I PI3K Provide Lipid Substrate in T Cell Autophagy Through Linked Activity of Inositol Phosphatases

Frontiers in Cell and Developmental Biology, 2021
Autophagy, a highly conserved intracellular process, has been identified as a novel mechanism regulating T lymphocyte homeostasis. Herein, we demonstrate that both starvation- and T cell receptor-mediated autophagy induction requires class I ...
Ian X. McLeod, Ruchi Saxena, Zachary Carico, You-Wen He   +3 more
doaj   +1 more source

ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms [PDF]

Cancer Science, 2007
Class I phosphatidylinositol 3 kinases (PI3K) phosphorylate phosphatidylinositol 4,5‐bisphosphate to generate phosphatidylinositol 3,4,5‐trisphosphate. These molecules play an important role in fundamental cellular responses. Four isoforms of class I PI3K are known to have different functions, and abnormalities in their activities have been related to ...
Dexin, Kong, Takao, Yamori
openaire   +2 more sources