Results 221 to 230 of about 5,400,969 (299)

A Bifunctional Protease Cleaves the Leader Peptide in the Biosynthesis of Class I Microviridins. [PDF]

Chembiochem
Brüssow N, Scholz S, Stindt A, Wiebach V, Damaszek T, Süssmuth RD, Dittmann E, Baunach M.   +7 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Clinical Outcomes of Ruxolitinib Treatment in Patients With IPSS Intermediate-1-Risk Myelofibrosis: Interim Analysis From an Italian, Prospective Study (ROMEI). [PDF]

Hematol Oncol
Guglielmelli P, Breccia M, Mendicino F, Martelli M, Di Renzo N, Palumbo GA, Crugnola M, Musso M, Sibilla S, Sportoletti P, Abruzzese E, Impera S, Malato A, Siragusa S, Selleri C, Pane F, Martino B, Ricco A, Gardellini A, Liberati AM, Tafuri A, Langella M, Brociner M, Ditonno P, Pastore D, Mulas O, Pocali B, De Gobbi M, Morsia E, Benevolo G, Elli EM, De Stefano V, Falcone AP, Vallisa D, Tomassetti S, Lunghi F, Orofino N, Carli G, Urbano T, Lucchesi A, Brunoventre M, Bonifacio M, Binotto G, Cavazzini F, Ranalli P, Allegra A, Anaclerico B, Mazzotta S, Gherlinzoni F, Tiribelli M, Castiglioni C, Landoni M, Valsecchi D, Magnoli M, Passamonti F, Palandri F.   +55 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Sleep-disordered breathing in patients with heart failure with preserved left ventricular ejection fraction. [PDF]

Sleep Breath
Grimm C, Viniol C, Degerli M, Hildebrandt O, Kesper K, Koehler U, Grimm W, Parahuleva M.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson's disease. [PDF]

Clin Epigenetics
Goodheart AE, Yoo CH, Fassini A, Dagnew TM, Ye R, Striar R, Quan M, Rattray AK, Meyer TN, Peterec E, Lee H, Fiedler SA, Hooker JM, Wey HY, Wang C, Gomperts SN.   +15 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

RAISE-FER: a massive cross-dataset augmented facial expression dataset. [PDF]

Front Robot AI
Palestra G, Palmisano D, De Carolis BN.
europepmc   +1 more source