Results 231 to 240 of about 12,130,137 (366)

Interest Rate and Growth Equilibrium in a Two-Class Neoclassical Model

, 1976
Shigetoshi Yamatani
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Heterogeneous Activity Profiles in Older Adults: A Latent Class Analysis and Validation With Health Outcomes. [PDF]

Cureus
Nakahara K, Fujii Y, Honda N, Kusuda K, Yamamoto T, Oba J.   +5 more
europepmc   +1 more source

Possible Conflicts of Interest with D&O Insurance in Event of Shareholders’ Class Actions

, 2013
Wim Weterings
openalex   +1 more source

EFFORTS TO OVERCOME THE LACK OF INTEREST IN READING REFERENCE BOOK OF COURSES IN THE ERA OF INDUSTRIAL REVOLUTION 4.0 (A STUDY OF MASTER STUDENTS IN ISLAMIC EDUCATION CLASS OF 2018)

, 2020
Muhtadin Muhtadin
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Segmentation-Based Multi-Class Detection and Radiographic Charting of Periodontal and Restorative Conditions on Bitewing Radiographs Using Deep Learning. [PDF]

Diagnostics (Basel)
Bayırlı AB, Kesgin B, Uytun M, Kuran A, Çitir M, Yavuz MB, Bayrakdar SK, Çelik Ö, Bayrakdar İŞ, Orhan K.   +9 more
europepmc   +1 more source

Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation

EcoSal Plus, 2018
A. Serio, T. Keepers, L. Andrews, K. Krause   +3 more
semanticscholar   +1 more source

Charting a New Course: Encouraging Programming Class Participation and Interest Through Multimedia and Flipped Classroom Activities [PDF]

I. Nikolov
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source