Results 51 to 60 of about 4,457,856 (245)

Semi-classical Green functions

, 2018
Let $H(x,p)\sim H_0(x,p)+hH_1(x,p)+\cdots$ be a semi-classical Hamiltonian on $T^*{\bf R}^n$, and $\Sigma_E=\{H_0(x,p)=E\}$ a non critical energy surface. Consider $f_h$ a semi-classical distribution (the "source") microlocalized on a Lagrangian manifold
Anikin, Anatoly, Dobrokhotov, Sergey, Nazaikinskii, Vladimir, Rouleux, Michel   +3 more
core   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diffusion of Classical Solitons

, 1998
We study the diffusion and deformation of classical solitons coupled to thermal noise. The diffusion coefficient for kinks in the $\phi^4$ theory is predicted up to the second order in $kT$.
Abdumalikov, Abrahams, Belavin, Büttiker, Büttiker, Castro-Neto, Davydov, Dziarmaga, Dziarmaga, Jacek Dziarmaga, Jackiw, Kaup, Manton, Satarić, Tuszyński, Ward, Wojtek Zakrzewski   +16 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Classical dynamics on graphs

, 2000
We consider the classical evolution of a particle on a graph by using a time-continuous Frobenius-Perron operator which generalizes previous propositions.
C. Appert, D. Alonso, E. Akkermans, F. Barra, F. Barra, G. Berkolaiko, H. Schanz, H. Schanz, K. Pance, M. H. Ernst, P. Cvitanović, P. Gaspard, P. Gaspard, P. Gaspard, P. Gaspard, P. Gaspard, P. Gaspard, P. Gaspard, P. Gaspard, P. Gaspard, P. Gaspard, P. Walters, R. B. Griffiths, R. Blümel, R. Blümel, T. Kottos, T. Kottos, T. Kottos   +27 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Nonseparability, Classical and Quantum [PDF]

, 2010
This paper examines the implications of the holonomy interpretation of classical electromagnetism. As has been argued by Richard Healey and Gordon Belot, classical electromagnetism on this interpretation evinces a form of nonseparability, something that ...
Myrvold, Wayne C.
core