Results 81 to 90 of about 2,324,779 (254)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Catalogue of the Northwestern Classical Academy, 1921-1922 [PDF]

, 1921
The catalogue of Northwestern Classical Academy from the academic year 1921-1922. The catalogue includes information about the Academy, including the names of board members, instructors, students, and alumni. It provides the course of study, the academic
Northwestern Classical Academy
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Classical and quantum information /

, 2012
A new discipline, Quantum Information Science, has emerged in the last two decades of the twentieth century at the intersection of Physics, Mathematics, and Computer Science. Quantum Information Processing is an application of Quantum Information Science
Marinescu, Gabriela M., Marinescu, Dan C.   +1 more
core  

Catalogue of the Northwestern Classical Academy, 1892-1893 [PDF]

, 1892
The catalogue of Northwestern Classical Academy from the academic year 1892-1893. The catalogue includes information about the Academy, including the names of board members, instructors, and students.
Northwestern Classical Academy
core   +1 more source

Kurgans of the Eastern Kugitang Piedmonts. Preliminary Report on Excavations in Seasons 2015–2017 [PDF]

Studia Hercynia, 2018
In its three field seasons between 2015 and 2017 the Czech‑Uzbekistani archaeological mission has focused on the area of the eastern Kugitang piedmonts, especially the Paskhurt Valley (southern Uzbekistan) in order to examine its historical cultural ...
Jakub Havlík, Ladislav Stančo, Jan Kysela, Petra Cejnarová, Hana Havlíková, Tatiana Votroubeková   +5 more
doaj  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Time reversal in classical electromagnetism [PDF]

, 2007
Richard Feynman has claimed that anti-particles are nothing but particles `propagating backwards in time'; that time reversing a particle state always turns it into the corresponding anti-particle state.
Arntzenius, Frank, Greaves, Hilary
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source