Results 111 to 120 of about 45,164 (282)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

The effects of temporal and spatial location of a CS paired with food on a pigeon's key-peck response [PDF]

open access: yes, 1979
The effects of a classical conditioning procedure on behavior maintained by an operant schedule of reinforcement were studied. A Change in color associated with response-independent food was presented to pigeons at different temporal locations within a ...
Hatten, Anna Dixon   +1 more
core  

Music in Advertisements for Unmentionable Products—A Classical Conditioning Experiment

open access: yes, 1988
This article describes an experiment used to determine the effects of liked or disliked music on preference for sensitive or ‘unmentionable’ products. It replicates experiments into the classical conditioning effects of music in advertisements conducted ...
Russell Abratt   +3 more
core   +1 more source

Implicit Self-Esteem manipulation using subliminal stimuli presentation [PDF]

open access: yesروانشناسی و روانپزشکی شناخت, 2015
Introduction: Studies of cognitive psychology in recent years has led to introduce of two types of explicit and implicit self-esteem. Several studies have shown that self-esteem could conditioned in a few minutes.
Bahram Maleki
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Model uncertainty in classical conditioning

open access: yes, 2003
We develop a framework based on Bayesian model averaging to explain how animals cope with uncertainty about contingencies in classical conditioning experiments.
D. S. Touretzky   +3 more
core  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

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