Results 141 to 150 of about 137,516 (336)

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Phenotypic characterization of human intermediate monocytes

Frontiers in Immunology, 2013
Daniëlle eHijdra, Daniëlle eHijdra, Adriane DM Vorselaars, Jan C Grutters, Jan C Grutters, Anke ME Claessen, Ger T Rijkers, Ger T Rijkers, Ger T Rijkers   +8 more
doaj   +1 more source

Chemotherapy-induced developmental trajectories of monocytes in breast cancer

RUDN Journal of Medicine
Relevance . Monocytes are circulating immune cells which are traditionally divided into three subsets. The contribution of each subset to breast cancer pathogenesis is controversial.
Tatiana S. Gerashchenko, Marina R. Patysheva, Anastasia A. Fedorenko, Anastasia P. Filatova, Maria A. Vostrikova, Olga D. Bragina, Anton A. Fedorov, Pavel S. Iamshchikov, Evgeny V. Denisov   +8 more
doaj   +1 more source

Different phenotypes of non‐classical monocytes associated with systemic inflammation, endothelial alteration and hepatic compromise in patients with dengue [PDF]

, 2018
Juan S. Naranjo‐Gómez, Jorge Andrés Castillo, Mauricio Rojas, Berta Nelly Restrepo, Francisco J. Díaz, Paula A. Velilla, Diana Castaño   +6 more
openalex   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Phenotypic features and subset composition of monocytes in acute pancreatitis

Медицинская иммунология
The aim of our research was to study the features of activation receptor expression on various subsets of blood monocytes in patients with acute pancreatitis (AP). 69 patients aged 37-62 years with moderateand severe-grade AP were examined. The diagnosis
A. A. Savchenko, D. E. Zdzitovetskiy, M. M. Adilov, I. V. Kudryavtsev, V. D. Belenyuk, A. G. Borisov   +5 more
doaj   +1 more source

In vitro Phenotype Induction of Circulating Monocytes: CD16 and CD163 Analysis

Journal of Inflammation Research, 2021
Claudio Karsulovic,1,2 Fabian Tempio,3,4 Mercedes Lopez,3,4 Julia Guerrero,1 Annelise Goecke1,2 1Laboratorio de Inmunomodulación Neuroendocrina, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile ...
Karsulovic C, Tempio F, Lopez M, Guerrero J, Goecke A   +4 more
doaj  

Classical Monocytes-Low Expressing Hla-Dr is Associated with Higher Mortality Rate in Sars-Cov-2+ Young Patients with Severe Pneumonia

, 2023
Juan Sebastián Henao Agudelo, Sebastian Ayala, Marisol Badiel, Andrés Felipe Zea-Vera, Lorena Matta Cortes   +4 more
openalex   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Immune targets in the tumor microenvironment treated by radiotherapy. [PDF]

, 2019
Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy.
Li, Jian Jian, Ozpiskin, Omer M, Zhang, Lu   +2 more
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