Results 61 to 70 of about 1,484,579 (174)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

African Swine Fever Virus Immunosuppression and Virulence-Related Gene

Current Issues in Molecular Biology
African swine fever virus (ASFV), a highly contagious pathogen characterized by a complex structure and a variety of immunosuppression proteins, causes hemorrhagic, acute, and aggressive infectious disease that severely injures the pork products and ...
Tao Huang, Fangtao Li, Yingju Xia, Junjie Zhao, Yuanyuan Zhu, Yebing Liu, Yingjuan Qian, Xingqi Zou   +7 more
doaj   +1 more source

The European Classical Swine Fever Virus Database: Blueprint for a Pathogen-Specific Sequence Database with Integrated Sequence Analysis Tools

Viruses, 2016
Molecular epidemiology has become an indispensable tool in the diagnosis of diseases and in tracing the infection routes of pathogens. Due to advances in conventional sequencing and the development of high throughput technologies, the field of sequence ...
Alexander Postel, Stefanie Schmeiser, Bernd Zimmermann, Paul Becher   +3 more
doaj   +1 more source

Evidence of West Nile Virus Infections in Wild Boars (Sus scrofa) in the Netherlands, 2018–2021

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Orthoflaviviruses are emerging in Europe and have potential significant impact on animal and public health. Usutu virus (USUV) and West Nile virus (WNV) have been first detected in the Netherlands in 2016 and 2020, respectively. Wild boars (Sus scrofa) have been suggested as an interesting population to detect the circulation of ...
Kiki Streng, Eduardo de Freitas Costa, Sophie van Oort, Renate Hakze‐van der Honing, Gebbiena Bron, Carl Andreas Grøntvedt, Wim H. M. van der Poel, Nathanaël Hozé, Michel Counotte   +8 more
wiley   +1 more source

Molecular Maneuvers and Host Sabotage: A Comprehensive Review of CSFV’s Multifaceted Strategies to Subvert Immune Defenses and Cellular Metabolism

Viruses
Classical swine fever virus (CSFV) remains a significant threat to the global swine industry, causing a highly contagious and often fatal disease in pigs.
Wenqiang Sun, Lu Xu, Jiaxin Li
doaj   +1 more source

Molecular Detection of Sarcocystis suihominis and Sarcocystis miescheriana in Wild Boars Hunted for Human Consumption in Poland Highlights a Potential Risk for the Consumer

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Wild boars and domestic pigs can act as intermediate hosts for two Sarcocystis species: Sarcocystis miescheriana and the zoonotic Sarcocystis suihominis. Humans become infected with S. suihominis by eating raw or undercooked meat. Herein we investigated the occurrence of Sarcocystis spp.
Weronika Korpysa‐Dzirba, Selene Rubiola, Ewa Bilska‐Zając, Francesco Chiesa, Mirosław Różycki, Aneta Bełcik, Małgorzata Samorek‐Pieróg, Stella Lovisolo, Petras Prakas, Agnė Baranauskaitė, Jacek Karamon, Jacek Sroka, Tomasz Cencek   +12 more
wiley   +1 more source

Protection Against Transplacental Transmission of a Highly Virulent Classical Swine Fever Virus Two Weeks After Single-Dose FlagT4G Vaccination in Pregnant Sows

Vaccines
Background/Objectives: Classical swine fever (CSF) continues to challenge global eradication efforts, particularly in endemic regions, where pregnant sows face heightened risks of vertical transmission following exposure to CSFV.
Liani Coronado, Àlex Cobos, Adriana Muñoz-Aguilera, Sara Puente-Marin, Gemma Guevara, Cristina Riquelme, Saray Heredia, Manuel V. Borca, Llilianne Ganges   +8 more
doaj   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene–Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo, Kaifei Guo, Fangyu Xiao, Ruoqi Wang, Junhui Guo, Qiaoyun Ren, Shuaiyang Zhao, Muhammad Kashif Obaid, Guiquan Guan, Hong Yin   +9 more
wiley   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Studies on the epidemiology of classical swine fever in the republic of Korea [PDF]

, 2012
Classical swine fever (CSF) is a serious and highly infectious viral disease of domestic pigs and wild boar, which is caused by a single stranded RNA pestivirus.
Che, Sunoh
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