Results 61 to 70 of about 2,472,663 (210)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

First isolation of Hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium. [PDF]

, 2011
Hepatitis E virus (HEV) genotypes 3 and 4 are a cause of human hepatitis and swine are considered the main reservoir. To study the HEV prevalence and characterize circulating HEV strains, fecal samples from swine in the Netherlands and Belgium were ...
Coillie, E., Van, Wim H M van der Poel, van der Poel, W.H.M., Antonis Adriaan F. G., Honing-Hakze, R.W., van der, Poel, W.H.M., van der, Van Coillie, E., Adriaan F. G. Antonis, Adriaan F G Antonis, van der Poel Wim H. M., van Coillie Els, Wim H. M. van der Poel, van der Honing-Hakze, R.W., Antonis, A.F.G., Hakze-van der Honing Renate W., Renate W. Hakze-van der Honing, Els van Coillie, Renate W Hakze-van der Honing   +17 more
core   +2 more sources

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic

Acta Paediatrica, EarlyView.
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley   +1 more source

Evidence of West Nile Virus Infections in Wild Boars (Sus scrofa) in the Netherlands, 2018–2021

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Orthoflaviviruses are emerging in Europe and have potential significant impact on animal and public health. Usutu virus (USUV) and West Nile virus (WNV) have been first detected in the Netherlands in 2016 and 2020, respectively. Wild boars (Sus scrofa) have been suggested as an interesting population to detect the circulation of ...
Kiki Streng, Eduardo de Freitas Costa, Sophie van Oort, Renate Hakze‐van der Honing, Gebbiena Bron, Carl Andreas Grøntvedt, Wim H. M. van der Poel, Nathanaël Hozé, Michel Counotte   +8 more
wiley   +1 more source

Transcriptomic and Metabolomic Profiling Identifies a Core Gene–Metabolite Axis Driving African Swine Fever Virus Replication in the Soft Tick Ornithodoros lahorensis

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Transcriptomic and metabolomic profiling of Ornithodoros lahorensis during African swine fever virus (ASFV) infection reveals that ASFV rewires host purine/pyrimidine metabolism, lipid metabolism, and energy metabolism. A core gene‐metabolite regulatory axis consisting of 12 key genes and 8 signature metabolites is identified to support viral genome ...
Jin Luo, Kaifei Guo, Fangyu Xiao, Ruoqi Wang, Junhui Guo, Qiaoyun Ren, Shuaiyang Zhao, Muhammad Kashif Obaid, Guiquan Guan, Hong Yin   +9 more
wiley   +1 more source

Cross-reactivities and cross-neutralization of different envelope glycoproteins E2 antibodies against different genotypes of classical swine fever virus

Frontiers in Veterinary Science, 2023
Classical swine fever (CSF) is a highly contagious swine disease caused by the classical swine fever virus (CSFV), wreaking havoc on global swine production. The virus is divided into three genotypes, each comprising 4–7 sub-genotypes. The major envelope
Wei-Tao Chen, Wei-Tao Chen, Hsin-Meng Liu, Hsin-Meng Liu, Hsin-Meng Liu, Chia-Yi Chang, Ming-Chung Deng, Yu-Liang Huang, Yen-Chen Chang, Yen-Chen Chang, Hui-Wen Chang, Hui-Wen Chang   +11 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Classical Swine Fever Virus p7 Protein Is a Viroporin Involved in Virulence in Swine [PDF]

Journal of Virology, 2012
ABSTRACT The nonstructural protein p7 of classical swine fever virus (CSFV) is a small hydrophobic polypeptide with an apparent molecular mass of 6 to 7 kDa. The protein contains two hydrophobic stretches of amino acids interrupted by a short charged segment that are predicted to form transmembrane helices and a cytosolic loop ...
Gladue, Douglas P., Holinka, Lauren G., Largo Pereda, Eneko, Fernández Sainz, Ignacio, Carrillo, Consuelo, O’Donnell, Vivian, Baker-Branstetter, Ryan, Lu, Zhiqiang, Ambroggio, Xavier, Risatti, Guillermo R., Nieva Escandón, José Luis, Borca, Manuel V.   +11 more
openaire   +3 more sources

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Analysis of synonymous codon usage in classical swine fever virus [PDF]

Virus Genes, 2008
Using the complete genome sequences of 35 classical swine fever viruses (CSFV) representing all three genotypes and all three kinds of virulence, we analyzed synonymous codon usage and the relative dinucleotide abundance in CSFV. The general correlation between base composition and codon usage bias suggests that mutational pressure rather than natural ...
Tao, Pan, Dai, Li, Luo, Mengcheng, Tang, Fangqiang, Tien, Po, Pan, Zishu   +5 more
openaire   +2 more sources