Results 41 to 50 of about 9,999 (172)

Classical swine fever: Unveiling the complexity through a multifaceted approach

Open Veterinary Journal
Classical swine fever (CSF), sometimes referred to as hog cholera, is a highly contagious, virally-based, systemic illness that affects both domestic and wild pigs.
Aswin Rafif Khairullah, Mustofa Helmi Effendi, Ikechukwu Benjamin Moses, Kartika Afrida Fauzia, Yulianna Puspitasari, Katty Hendriana Priscilia Riwu, Ima Fauziah, Ricadonna Raissa, Otto Sahat Martua Silaen, Syahputra Wibowo, Sheila Marty Yanestria, Muhammad Khaliim Jati Kusala, Syafiadi Rizki Abdila, Bima Putra Pratama, Abdullah Hasib   +14 more
doaj   +1 more source

Classical swine fever virus: the past, present and future

Virus Research, 2020
Classical swine fever (CSF) is among the most relevant viral epizootic diseases of swine. Due to its severe economic impact, CSF is notifiable to the world organisation for animal health. Strict control policies, including systematic stamping out of infected herds with and without vaccination, have permitted regional virus eradication.
Ganges L, Crooke HR, Bohórquez JA, Postel A, Sakoda Y, Becher P, Ruggli N   +6 more
openaire   +4 more sources

Mutations in Classical Swine Fever Virus NS4B Affect Virulence in Swine [PDF]

Journal of Virology, 2010
ABSTRACT NS4B is one of the nonstructural proteins of classical swine fever virus (CSFV), the etiological agent of a severe, highly lethal disease of swine. Protein domain analysis of the predicted amino acid sequence of the NS4B protein of highly pathogenic CSFV strain Brescia (BICv) identified a putative Toll/interleukin-1 receptor (TIR ...
I, Fernandez-Sainz, D P, Gladue, L G, Holinka, V, O'Donnell, I, Gudmundsdottir, M V, Prarat, J R, Patch, W T, Golde, Z, Lu, J, Zhu, C, Carrillo, G R, Risatti, M V, Borca   +12 more
openaire   +2 more sources

Immune responses against classical swine fever virus: between ignorance and lunacy

Frontiers in Veterinary Science, 2015
Classical swine fever virus infection of pigs causes disease courses from life-threatening to asymptomatic, depending on the virulence of the virus strain and the immunocompetence of the host.
Artur eSummerfield, Nicolas eRuggli
doaj   +1 more source

The E2 Glycoprotein of Classical Swine Fever Virus Is a Virulence Determinant in Swine [PDF]

Journal of Virology, 2005
ABSTRACT To identify genetic determinants of classical swine fever virus (CSFV) virulence and host range, chimeras of the highly pathogenic Brescia strain and the attenuated vaccine strain CS were constructed and evaluated for viral virulence in swine.
G R, Risatti, M V, Borca, G F, Kutish, Z, Lu, L G, Holinka, R A, French, E R, Tulman, D L, Rock   +7 more
openaire   +2 more sources

Assessing the Protective Dose of a Candidate DIVA Vaccine against Classical Swine Fever

Vaccines, 2021
Classical swine fever is a highly contagious and deadly disease in swine. The disease can be controlled effectively by vaccination with an attenuated virus known as the “Chinese” (C)-strain.
Tinka Jelsma, Jacob Post, Erwin van den Born, Ruud Segers, Jeroen Kortekaas   +4 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Vaccination influences the evolution of classical swine fever virus

Infection, Genetics and Evolution, 2014
Classical swine fever is a serious, economically damaging disease caused by classical swine fever virus (CSFV). The CSFV is composed of two clades, according to phylogenetic estimates. Attenuated live vaccine such as HCLV, has been widely used to protect pigs from CSFV, but the influence of vaccination on the evolution of CSFV has not been studied.
Wei Ji, Dan-Dan Niu, Hong-Li Si, Nai-Zheng Ding, Cheng-Qiang He   +4 more
openaire   +2 more sources

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Determinants of Virulence of Classical Swine Fever Virus Strain Brescia [PDF]

Journal of Virology, 2004
ABSTRACT Two related classical swine fever virus (CSFV) strain Brescia clones were isolated from blood samples from an infected pig. Virus C1.1.1 is a cell-adapted avirulent variant, whereas CoBrB is a virulent variant. Sequence analysis revealed 29 nucleic acid mutations in C1.1.1, resulting in 9 amino acid substitutions ...
van Gennip, H.G.P., Vlot, A.C., Hulst, M.M., de Smit, A.J., Moormann, R.J.M.   +4 more
openaire   +2 more sources