Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Review of: Annmarie Drury, Translation as Transformation in Victorian Poetry (Cambridge Studies in Nineteenth-Century Literature and Culture). Cambridge: Cambridge University Press, 2015. Hardback. Pp. viii + 293 [PDF]
, 2017 No abstract ...
Williams, Rhian
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Playing simplicity: polemical stupidity in the writing of the French Enlightenment [PDF]
, 2002 Polemical stupidity - a critical concept drawn from Bakhtin – denotes the strategic refusal to understand. It appears most familiarly in the character of the Fool (like Candide), who genuinely does not understand the world, thus unmasking its ...
Howells, Robin
core
International Journal of Theoretical Physics, 1990 12 pages, 2 ...
Cohn, Arthur, Rabinowitz, Mario
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The development of the French novel from Madame de la Fayette to Pierre Loti. [PDF]
, 1916 Thesis (M.A.)--Boston ...
Stinchfield, Ben
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Hardy and God: Tess of the D\u27Urberville\u27s Role as the Ultimate Pawn [PDF]
, 2006 Thomas Hardy\u27s Tess of the D \u27Urbervilles has multiple competing claims which are difficult to reconcile within the schools ofhist0l1cal, feminist, or classical criticism. A better way to approach the novel is to look at Tess as a pawn within Hardy\
Hamann, Georgia
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source