Results 131 to 140 of about 134,599 (345)

Improved split fluorescent proteins for endogenous protein labeling. [PDF]

, 2017
Self-complementing split fluorescent proteins (FPs) have been widely used for protein labeling, visualization of subcellular protein localization, and detection of cell-cell contact.
Feng, Siyu, Huang, Bo, Leonetti, Manuel D, Li, Han, Pessino, Veronica, Sekine, Sayaka   +5 more
core   +2 more sources

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Seamlessly Overcoming Biological Barriers with a Small Photosensitizer to Treat Metastatic Tumors with Photodynamic Therapy

Angewandte Chemie, EarlyView.
LUZ 51 is a relatively small and amphiphilic photosensitizer that accumulates in poorly‐vascularized tumors, is rapidly internalized by cancer cells, does not elicit skin photosensitivity and triggers robust immunological responses that reduce spontaneous metastasis.
Mafalda Penetra, Bárbara Lima, João P. A. Campos, Sara M. A. Pinto, Fábio A. Schaberle, Mariette M. Pereira, Luis G. Arnaut, Lígia C. Gomes‐da‐Silva   +7 more
wiley   +2 more sources

Clathrin mediates membrane fission and budding by constricting membrane pores

Cell Discovery
Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clathrin, to form Ω-shape profiles and helix ...
Lisi Wei, Xiaoli Guo, Ehud Haimov, Kazuki Obashi, Sung Hoon Lee, Wonchul Shin, Min Sun, Chung Yu Chan, Jiansong Sheng, Zhen Zhang, Ammar Mohseni, Sudhriti Ghosh Dastidar, Xin-Sheng Wu, Xin Wang, Sue Han, Gianvito Arpino, Bo Shi, Maryam Molakarimi, Jessica Matthias, Christian A. Wurm, Lin Gan, Justin W. Taraska, Michael M. Kozlov, Ling-Gang Wu   +23 more
doaj   +1 more source

Protein-dependent membrane remodeling in mitochondrial morphology and clathrin-mediated endocytosis [PDF]

, 2021
Daryna Tarasenko, Michael Meinecke
openalex   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Nanomanipulation of Ligand Nanogeometry Modulates Integrin/Clathrin-Mediated Adhesion and Endocytosis of Stem Cells [PDF]

, 2023
Bohan Yin, Qin Zhang, Jiaxiang Yan, Yingying Huang, Chuanqi Li, Jiareng Chen, Chunyi Wen, Siu Hong Dexter Wong, Mo Yang   +8 more
openalex   +1 more source

Nitrogen‐Boosted H2O2 Production of Arginine‐Polyphenol Nanozyme Drives Oxidative Eustress for Hair Regeneration

Advanced Science, EarlyView.
PEA nanoenzymes are assembled from L‐arginine and EGCG. The nitrogen element in arginine enhances the thermodynamic feasibility of H2O2 production through PEA's oxygen reduction catalysis, enabling nitrogen‐dependent H2O2 release. Intradermal delivery of PEA via microneedles promotes efficient H2O2 synthesis, thereby stimulating regrowth in telogen ...
Yifei Wang, Yaojia Yang, Aoxue Wang, Chen Shen, Shenliang Tan, Changsheng Liu, Yuzheng Zhao, Xue Qu   +7 more
wiley   +1 more source

Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval

Frontiers in Cellular Neuroscience, 2018
Efficient retrieval of the synaptic vesicle (SV) membrane from the presynaptic plasma membrane, a process called endocytosis, is crucial for the fidelity of neurotransmission, particularly during sustained neural activity.
Yasunori Mori, Shigeo Takamori
doaj   +1 more source

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

Advanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv, Pengshuai Yan, Huan Chen, Guangxian Li, Yiyue Zhao, Yanhui Chen, Qingguo Du, Wen‐Xue Li   +7 more
wiley   +1 more source