Results 151 to 160 of about 126,267 (387)
The Journal of Cell Biology, 2004 Endocytic cargos are ensheathed in a clathrin coat—a complicated woven lattice that looks like it could never be pried apart. Yet uncoating occurs soon after vesicles are released from the plasma membrane, thanks to Hsc70 and its cochaperone auxilin. New structures of the clathrin coat with and without auxilin reveal a possible latch that might spring ...
openaire +2 more sources
Advanced Science, EarlyView.A novel tri‐specific recombinant protein and its drug conjugate are developed, named sRP‐EHI and sRPDC‐EHI, which feature a star‐shaped topological structure. It can simultaneously bind the EGFR, HER2, and integrin αvβ3 overexpressed in cancer cells.
Huiyi Jiang +6 more
wiley +1 more source
Non-specific cellular uptake of surface-functionalized quantum dots
, 2010 We report a systematic empirical study of nanoparticle internalization into cells via non-specific pathways. The nanoparticles were comprised of commercial quantum dots (QDs) that were highly visible under a fluorescence confocal microscope.
Goldys, E M +5 more
core +1 more source
Deciphering dynamics of clathrin-mediated endocytosis in a living organism
Journal of Cell Biology, 2016 Ferguson et al. demonstrate that clathrin coat growth rates can be utilized as quantitative reporters of clathrin-mediated endocytic dynamics in cellular contexts where errors associated with single-particle tracking are significant.
J. Ferguson +5 more
semanticscholar +1 more source
Molecular Signatures Underlying Synaptic Vesicle Cargo Retrieval
Frontiers in Cellular Neuroscience, 2018 Efficient retrieval of the synaptic vesicle (SV) membrane from the presynaptic plasma membrane, a process called endocytosis, is crucial for the fidelity of neurotransmission, particularly during sustained neural activity.
Yasunori Mori, Shigeo Takamori
doaj +1 more source
Advanced Science, EarlyView.To solve the challenge of PROTACs in clinical potential due to poor water solubility and membrane permeability, a nanodelivery system based on lipid nanodisks loaded with MZ1 prodrug (LND‐MZ1) to remodel the physicochemical and pharmacokinetic properties of PROTAC MZ1 is elaborately proposed.
Meichen Pan +6 more
wiley +1 more source
Clathrin regenerates synaptic vesicles from endosomes
Nature, 2014 Ultrafast endocytosis can retrieve a single, large endocytic vesicle as fast as 50–100 ms after synaptic vesicle fusion. However, the fate of the large endocytic vesicles is not known.
Shigeki Watanabe +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang +12 more
wiley +1 more source
Nature CommunicationsClathrin forms a triskelion, or three-legged, network that regulates cellular processes by facilitating cargo internalization and trafficking in eukaryotes.
Lucas A. Defelipe +9 more
doaj +1 more source