Results 151 to 160 of about 63,639 (257)

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Functions of J‐domain proteins in mitochondrial protein biogenesis

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...
Vitasta Tiku, Georg Bossenz, Janine Kirstein, Thomas Becker   +3 more
wiley   +1 more source

Adhesive Photoinitiator Constructs Polymer Jackets on Enzymes: Direct, Release‐Free Cytosolic Delivery

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
A supramolecular adhesive photoinitiator, GuCD⊃BP‐SH, overcomes a central dilemma in enzyme therapeutics. The initiator, featuring a guanidinium‐modified cyclodextrin (GuCD) host, triggers formation of a semi‐permeable polymer jacket directly on an enzyme.
Shuran He, Soumen Ghosh, Kou Okuro
wiley   +2 more sources

CCDC32 stabilizes clathrin-coated pits and drives their invagination. [PDF]

Elife
Yang Z, Yang C, Huang Z, Xu P, Li Y, Han L, Peng L, Wei X, Pak JE, Svitkina T, Schmid SL, Chen Z.   +11 more
europepmc   +1 more source

Evaluating the potential of RNA interference for control of striped cucumber beetle, Acalymma vittatum (Fabricius) (Coleoptera: Chrysomelidae)

Pest Management Science, Volume 82, Issue 4, Page 3591-3602, April 2026.
SCB has a robust RNAi response to injected dsRNA, but oral RNAi is less efficient. Nucleases do not appear to be responsible for the discrepancy, suggesting other factors are involved. Abstract BACKGROUND The striped cucumber beetle (SCB) is a serious pest of cucurbit crops, causing damage both by feeding on plants and by vectoring plant diseases ...
Emine Kaplanoglu, Félix Longpré, Cam Donly   +2 more
wiley   +1 more source

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3054-3069, April 2026.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source

Roles in physiology and disease of the inositol phosphatase synaptojanin 1. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids
De Camilli P.
europepmc   +1 more source

Clathrin anchors

Clathrin anchors
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

Proteomic Analysis Reveals Accompanying Anion‐Dependent Changes of Cadmium Toxicity During Arabidopsis thaliana Development

Plant, Cell &Environment, Volume 49, Issue 4, Page 2069-2079, April 2026.
ABSTRACT Cadmium (Cd) is a significant environmental pollutant with widespread detrimental effects on living organisms, making it a frequent subject of laboratory studies. However, different types of Cd salts are used to spike media, often without considering the possibility that accompanying anions may influence the effects of metal cations. Using two
Martin Lyčka, Anna Vávra, David Potěšil, Ondřej Helia, Lukáš Fojt, Jiří Fajkus, Miloslava Fojtová   +6 more
wiley   +1 more source

Optimizing mRNA delivery with targeted elastin-like polypeptide-based LENN formulations: Insights into the endocytosis mechanism. [PDF]

Proc Natl Acad Sci U S A
Darji S, Qu F, Henager M, Prasad A, Elzey BD, Ferreira CR, Thompson DH.   +6 more
europepmc   +1 more source