Results 131 to 140 of about 64,892 (258)

Lipid-anchored melanotransferrin mediates transferrin-independent iron uptake and ferritin storage in mammals. [PDF]

Cell Death Discov
Tian MM, Tiong JWC, Gabathuler R, Martens G, Humphrey EC, Jefferies WA.   +5 more
europepmc   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

DNAJC6 Parkinson's disease: Endolysosomal dysfunction and emerging roles for oligodendrocytes. [PDF]

NPJ Parkinsons Dis
Allen AG, Stednitz S, Lardelli M, Barthelson K.   +3 more
europepmc   +1 more source

AlignPCA‐2D: PCA‐reduced Euclidean vector alignment for 2D classification in cryo‐EM

Acta Crystallographica Section D, EarlyView.
We introduce AlignPCA‐2D, a PCA‐space Euclidean alignment method for rapid and interpretable 2D classification of cryo‐EM particle images. The approach preserves essential structural variability while greatly reducing computational cost, offering a lightweight alternative to existing large‐scale cryo‐EM classification pipelines.Cryogenic electron ...
E. Ramírez-Aportela, O. L. Zarrabeitia, Y. C. Fonseca, T. Ceska, S. Subramaniam, J. M. Carazo, C. O. S. Sorzano   +6 more
wiley   +1 more source

Iflaviruses in arthropods: when small is mighty

Insect Science, EarlyView.
Many arthropod species harbor iflaviruses, which often cause covert (asymptomatic) infections, but may still affect host fitness. We review the impact of iflaviruses on arthropod fitness, immunity, behaviour as well as the iflavirus’ host range, transmission, tissue tropism and the interactions with other microorganisms within arthropods.
Annamaria Mattia, Hannah‐Isadora Huditz, Monique M. van Oers, Vera I.D. Ros   +3 more
wiley   +1 more source

Abnormal Endocytosis Resulting from Imbalanced Proteomic Doses in Human Aneuploid Embryos. [PDF]

Reprod Sci
Duan R, Liang X, Yang Y, Guo J.
europepmc   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

mTORC1-signaling switches megalin function from endocytosis to cell cycle progression. [PDF]

Cell Mol Life Sci
Dahlke E, Kunke M, Knöfler H, Anan Y, Shen Y, Zhao D, von Toerne C, Theilig F.   +7 more
europepmc   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

ELAPOR1 mediated vesicle traffic is required for acrosome biogenesis and male fertility in mice. [PDF]

Cell Mol Life Sci
Ding R, Guo Q, Wang L, Tang N, Fang X, Xin Z, Zhao W, Liu Y.   +7 more
europepmc   +1 more source