The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Heat shock induces Arc/Arg3.1 Cys34‐Cys159 disulfide crosslinking, promoting oligomerization and Hsp70‐CHIP‐dependent ubiquitination followed by proteasomal degradation during recovery. Disrupting disulfide formation (C159A) impairs CHIP‐mediated ubiquitination and stabilizes Arc/Arg3.1, whereas HSF1 loss limits inducible Hsp70 and leads to Arc ...
Dami So +7 more
wiley +1 more source
Large-scale identification of plasma membrane repair proteins revealed spatiotemporal cellular responses to plasma membrane damage. [PDF]
ElifeYamazaki Y, Kono K.
europepmc +1 more source
1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis. [PDF]
Nat CommunLiao W +14 more
europepmc +1 more source
Redox‐Activated Probes Enable High‐Contrast Live Imaging of Native Postsynaptic Scaffolds
Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.Sylives are modified fluorescent peptides for high‐contrast live imaging of inhibitory (gephyrin) and excitatory (PSD‐95) postsynaptic scaffolds in native neurons. Clean labeling requires low nanomolar probe levels, whereas uptake needs micromolar cell‐penetrating peptide (CPP).
Christiane Huhn +10 more
wiley +1 more source
Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects. [PDF]
RSC Med ChemZhang C +6 more
europepmc +1 more source
Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles. [PDF]
Cell RepLiu HY +6 more
europepmc +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 547-561, March 2026.ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons. [PDF]
Sci AdvHeger LM +14 more
europepmc +1 more source