Results 181 to 190 of about 115,227 (298)

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells. [PDF]

Proc Natl Acad Sci U S A
Smith SL, Zhan T, Li W, De Belly H, Zhang Q, Xu K, Weiner OD, Drubin DG.   +7 more
europepmc   +1 more source

Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research

Insect Molecular Biology, EarlyView.
Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley   +1 more source

From bolinaquinone, a marine hydroxyquinone sesquiterpene, to naphthoquinones with clathrin inhibitory effects. [PDF]

RSC Med Chem
O'Brien NS, Ghods A, Xue J, Garson MJ, Yong KWL, Sakoff JA, Glibert J, Chircop M, Fink U, Haucke V, Robinson PJ, McCluskey A.   +11 more
europepmc   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

Cellular uptake of extracellular dsRNA is tissue-dependent in insects. [PDF]

BMC Biol
Shi X, Liu Y, Liu X, Abbas M, Merchant A, Merzendorfer H, Zhao Z, Zhou X, Zhu KY, Zhang J.   +9 more
europepmc   +1 more source

Towards an integrated molecular understanding of plant hormones

Journal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain, Marie‐Laure Fauconnier, Manon Genva   +2 more
wiley   +1 more source

G6PD facilitates axon regeneration via clathrin-mediated endocytosis. [PDF]

J Biol Chem
Jiang C, Liu X, Li H, Lu Y, Cao Q, Yu B, Mao S.   +6 more
europepmc   +1 more source

Porphyromonas gingivalis Outer Membrane Vesicles‐Associated DNA Triggers Inflammation by Inducing IL‐6 in Astrocytes

Molecular Oral Microbiology, EarlyView.
Pg releases OMVs which contain Pg genomic DNA. The Pg OMVs‐associated DNA is incorporated into astrocytes via endocytosis and increases IL‐6 mRNA expression via TLR9. These effects of Pg OMVs may induce neuroinflammation, which could contribute to the onset and progression of AD in periodontal disease.
Ayu Takai, Kaya Yoshida, Yuka Hiroshima, Ayu Ikuta, Mariko Seyama, Yuta Uemura, Hiromichi Yumoto, Kazumi Ozaki   +7 more
wiley   +1 more source

Temporal Dynamics and Uptake Mechanisms of Carbonated Hydroxyapatite Nanoparticles in Murine F‑OST Cells. [PDF]

ACS Omega
Sobrinho JHS, Martins MG, Matioszek GV, Rossi AM, Pontes BACC, Borghi FF, Bonfim DC, Gemini-Piperni S.   +7 more
europepmc   +1 more source