Functional analysis from ex-vivo characterization of LDLR exon 13-15 duplication associated to familial hypercholesterolemia. [PDF]
Martínez C +8 more
europepmc +1 more source
Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy
Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen +9 more
wiley +1 more source
<i>BIRC5</i> Promoter-Driven Nanodrugs Suppress BIRC5-Positive Cancers Independent of ABCB1 Status and IDO1 Expression. [PDF]
Chang YC +5 more
europepmc +1 more source
Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle
ABSTRACT Integrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative genomics, leveraging population and functional genomic data, can be employed to ...
Gillian P. McHugo +10 more
wiley +1 more source
GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases
ABSTRACT Golgi‐localized gamma‐ear‐containing Arf‐binding proteins (GGAs) are a family of monomeric clathrin adaptors that function in intracellular vesicle trafficking. The three GGA family members—GGA1, GGA2 and GGA3—were first identified as sorting adaptors almost simultaneously by independent research groups in 2000. It is now well established that
Qinqin Wang +5 more
wiley +1 more source
Modulation of host cell pathways by <i>Coxiella burnetii</i> Dot/Icm effectors. [PDF]
Yuan J, Zhang Y, Song L, Luo ZQ.
europepmc +1 more source
Outer membrane vesicles hijack TIM-1 for cellular uptake. [PDF]
MacNair CR +7 more
europepmc +1 more source
Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction. [PDF]
Gunning V +8 more
europepmc +1 more source
CCDC32 stabilizes clathrin-coated pits and drives their invagination. [PDF]
Yang Z +11 more
europepmc +1 more source

