Results 221 to 230 of about 80,290 (296)

DNAJC6 Parkinson's disease: Endolysosomal dysfunction and emerging roles for oligodendrocytes. [PDF]

NPJ Parkinsons Dis
Allen AG, Stednitz S, Lardelli M, Barthelson K.   +3 more
europepmc   +1 more source

Mesenchymal Stem Cell‐Derived Extracellular Vesicles Ameliorate NaIO3‐Induced Dry AMD by Delivering miR‐486‐3p to Inhibit Lipocalin‐2‐Mediated Ferroptosis

MedComm, Volume 7, Issue 10, October 2026.
Our study reveals a novel mechanism by which MSC‐derived EVs alleviate NaIO3‐induced dry AMD‐like pathology. MSC‐EVs deliver miR‐486‐3p into retinal cells to directly inhibit the ferroptosis‐promoting target gene Lcn2. Concurrently, downregulated Lcn2 restores intracellular Gpx4 expression, thereby suppressing ferroptosis and rescuing retinal ...
Zheng Li, Tujing Zhao, Lin Ye, Runze Li, Huaping Tian, Ruilin Liao, Lulin Huang   +6 more
wiley   +1 more source

Arabidopsis ECHIDNA Plays an Important Role in Auxin Regulation of Clathrin-Mediated Trafficking During Root Gravitropism. [PDF]

Plant Cell Environ
Xu M, Shao Y, Wang Y, Zhu C, Wang L, Wu J, Shou J, Wang C, Yan X.   +8 more
europepmc   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Abnormal Endocytosis Resulting from Imbalanced Proteomic Doses in Human Aneuploid Embryos. [PDF]

Reprod Sci
Duan R, Liang X, Yang Y, Guo J.
europepmc   +1 more source

Identification of broadly expressed nervous system‐related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys

Pest Management Science, Volume 82, Issue 10, Page 9870-9878, October 2026.
Broadly expressed genes outperformed brain‐enriched neural targets as RNAi candidates in Halyomorpha halys. Microinjection of dsRNA targeting alpha‐soluble NSF attachment protein (Asnap) or Ras opposite protein (Rop) caused strong feeding suppression and near‐complete mortality, identifying them as promising targets for future oral or spray‐based RNAi ...
Nirakar Panda, Aline Koch, Venkata Partha Sarathi Amineni   +2 more
wiley   +1 more source

ELAPOR1 mediated vesicle traffic is required for acrosome biogenesis and male fertility in mice. [PDF]

Cell Mol Life Sci
Ding R, Guo Q, Wang L, Tang N, Fang X, Xin Z, Zhao W, Liu Y.   +7 more
europepmc   +1 more source

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

Enhanced dsRNA Production via a Three-Terminator Vector and Transcriptomic Correlates of RNAi Exposure in Thrips. [PDF]

Insects
Tian L, Xu G, Li J, Zhang Y, Shang W, Xie J, Gu Y, Huang Y, Tang X.   +8 more
europepmc   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source