Results 231 to 240 of about 80,290 (296)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

mTORC1-signaling switches megalin function from endocytosis to cell cycle progression. [PDF]

Cell Mol Life Sci
Dahlke E, Kunke M, Knöfler H, Anan Y, Shen Y, Zhao D, von Toerne C, Theilig F.   +7 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, Volume 600, Issue 17, Page 2564-2578, September 2026.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

AXL mediates influenza A virus entry and drives virus-induced inflammation. [PDF]

Emerg Microbes Infect
Zuo W, He D, Wang D, Lyu C, Xu J, Zheng Y, Wang W, Li H, Tan W, Wang Z, Cao B.   +10 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, Volume 600, Issue 17, Page 2547-2563, September 2026.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

From Uptake to Therapeutic Function in Engineered Exosome Delivery Systems. [PDF]

Research (Wash D C)
Li Y, Jin L, Gao P, Li M, Zhao Z, Jiang J, An M, Li F.   +7 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, Volume 600, Issue 17, Page 2437-2450, September 2026.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

MMP8 exacerbates sepsis-induced pulmonary vascular leakage by disruption of endothelial VE-cadherin through ERK signalling. [PDF]

Mol Biomed
Peng Y, Wu Q, Liu Y, Jing D, Bai Y, Zhu H.   +5 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, Volume 20, Issue 9, Page 2220-2242, September 2026.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy. [PDF]

Adv Intell Syst
Hallgrimson C, Li YL, Shou CA, Cardoen B, Lim J, Wong TH, Khater IM, Nabi IR, Hamarneh G.   +8 more
europepmc   +1 more source