Results 231 to 240 of about 115,227 (298)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy. [PDF]

Theranostics
Li Y, Zhou Z, Lv Y, Hu H, Chen M, Lei K, Gong C, Liu J, Yang L, Huang L, Liu W, Li J, Ye M, Zhu X, Huang K.   +14 more
europepmc   +1 more source

Nanosilicates Enhanced Periodontal Angiogenesis by Regulating Microtubule Dynamic‐Mediated STAT3 Pathway

Cell Proliferation, Volume 59, Issue 5, May 2026.
Nanosilicates triggered MAP4‐dependent microtubule remodelling via the ROS/MAPK pathway, shifting microtubules into a dynamic active state, which subsequently promoted activation of the STAT3 pathway, ultimately facilitating periodontal angiogenesis.
Lingling Shang, Yuhan Hu, Shaohua Ge
wiley   +1 more source

VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's neurons. [PDF]

Sci Adv
Heger LM, Gubinelli F, Huber AJ, Cardona-Alberich A, Rovere M, Matti U, Müller SA, Nagaraja SR, Jaschkowitz L, Schifferer M, Wurst W, Lichtenthaler SF, Behrends C, Sambandan S, Burbulla LF.   +14 more
europepmc   +1 more source

Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness

Genes to Cells, Volume 31, Issue 3, May 2026.
COP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Eun‐Hye Jeon, An‐Na Bae, Hajin Lee, Keon Uk Park, Hyun Mu Shin, Jong Ho Park, Kwang Seok Kim, In‐Chul Park, Yun‐Han Lee   +8 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia. [PDF]

FEBS Lett
Cullen JM, Nakatsugawa AC, Barton N, Haines H, Stein GS, Stein JL, Wechsler DS, Heath JL.   +7 more
europepmc   +1 more source

Isolation and characterization of a functionally active protein translocation apparatus from chloroplasts envelopes [PDF]

, 1993
Morré, D. James, Soll, Jürgen, Waegemann, Karin   +2 more
core  

Cell‐type‐specific gating of gene regulatory modules as a hallmark of early immune responses in Arabidopsis leaves

New Phytologist, Volume 250, Issue 4, Page 2007-2025, May 2026.
Summary In plants, multiple cell types contribute to immunity, but what division of labor exists among cell types when immunity is activated? We compared, at single‐cell resolution, the response of Arabidopsis thaliana leaf cells during pattern‐triggered and effector‐triggered immunity (PTI/ETI), sampled at 3 and 5 h after infection with Pseudomonas ...
Shanshan Wang, Ilja Bezrukov, Pin‐Jou Wu, Hannah Gauß, Marja Timmermans, Detlef Weigel   +5 more
wiley   +1 more source

A cluster of acidic residues in the cytoplasmic domain of SARS-CoV-2 Spike is required for virion-incorporation and infectivity. [PDF]

PLoS One
Stoneham CA, Singh R, De Leon A, Tafelmeyer P, Acosta F, Fuori A, Anderson M, Ramirez PW, Schwartzer-Sperber HS, Pillai S, Lewinski MK, Guatelli J.   +11 more
europepmc   +1 more source

GABRB3 Gene Polymorphisms Influences the Analgesic Response to Acupuncture Treatment in Patients With Chronic Knee Pain: A Randomized Controlled Neuroimaging Transcriptomics Study

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Study on KOA chronic knee pain patients shows GABRB3 rs4906902 polymorphism influences acupuncture analgesic efficacy, related to gray matter volume and gene expression in pain‐modulating brain regions. ABSTRACT The mechanisms underlying individual variability in acupuncture analgesia among patients with chronic pain remain unclear.
Sai Wu, Wanxia Wu, Jun Zhou, Shirui Cheng, Xiaohui Dong, Yang Chen, Chenjian Tang, Wenhua He, Fang Zeng, Fanrong Liang, Zhengjie Li   +10 more
wiley   +1 more source