LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens
LUCID: A computational pipeline for RNAi‐based biofungicide design. ABSTRACT Phytopathogenic fungi pose an escalating threat to global food security and ecosystem stability, as resistance and environmental concerns diminish the effectiveness of conventional fungicides.
Lucía Jiménez‐Castro +4 more
wiley +1 more source
Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite. [PDF]
Miao J +10 more
europepmc +1 more source
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz +8 more
wiley +1 more source
Membrane-associated periodic skeleton regulates major forms of endocytosis in neurons through a signaling-driven positive feedback loop. [PDF]
Fei J +4 more
europepmc +1 more source
Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda +6 more
wiley +1 more source
Heat shock proteins at the crossroads of endosomal trafficking pathways. [PDF]
Zuppini F +4 more
europepmc +1 more source
Histiocytes: Multifaceted Regulators of Health and Disease
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Picalm coordinates clathrin-mediated endocytosis and actin remodeling during myogenesis. [PDF]
Gaugel J +15 more
europepmc +1 more source
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects [PDF]
Diamond, Michael S +2 more
core +2 more sources

