Results 191 to 200 of about 64,892 (258)

Tumour‐Derived Extracellular Vesicles Induce Diffuse Large B‐Cell Lymphoma Progression Through Macrophage‐Mediated MDSC Accumulation

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Elevated peripheral myeloid‐derived suppressor cells (MDSCs) predicted suppressed anti‐tumour immunity and poor prognosis in diffuse large B‐cell lymphoma (DLBCL) patients. Here we demonstrated that tumour‐derived extracellular vesicles (EVs) served as a messenger, delivering cholesterol from lymphoma cells to macrophages.
Mengke Liu, YingYu Dong, Qixiao Guan, JianBiao Wang, Qing Shi, RongGui Lin, Muchen Zhang, Di Fu, Shu Cheng, Pengpeng Xu, Eurydice Angeli, Guilhem Bousquet, Wenguo Cui, Hongjing Dou, Wei‐Li Zhao, Li Wang   +15 more
wiley   +1 more source

Mannose-6-Phosphate-Tagged Liposomes Exhibit Increased Transcytosis Across Human Blood-Brain Barrier Model. [PDF]

Pharmaceutics
Dinamarca MC, Sevarika B, McNeil S.
europepmc   +1 more source

Theranostic Advancements in Brain Cancer: Promising Approaches for Emerging Therapy

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Strategies for improving intra‐arterial administration (A) and photodynamic therapy in brain cancer (B). Improving intra‐arterial (IA) administration and photodynamic therapy (PDT) for brain cancer involves enhancing tumor targeting and breaching the blood–brain barrier (BBB). Key strategies include super selective catheterization, using osmotic agents
Bipraban Khanra, Manoj Kumar Sarangi
wiley   +1 more source

Intrinsic conformational equilibria position arrestin‐2 for activation

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Arrestins regulate G protein‐coupled receptor (GPCR) signaling by undergoing large‐scale conformational rearrangements, yet the solution‐state equilibria that underlie arrestin pre‐activation remain poorly defined. While prior studies identified slow conformational exchange at the interdomain interface, these minor states could not be ...
Tucker J. Shriver, Kerem Kahraman, Mingzhe Pan, Çağdaş Dağ, Marco Tonelli, Scott A. Robson, Joshua J. Ziarek   +6 more
wiley   +1 more source

Heat shock proteins at the crossroads of endosomal trafficking pathways. [PDF]

Cell Biol Toxicol
Zuppini F, Renzullo L, Tornatore F, Poggio P, Brancaccio M.   +4 more
europepmc   +1 more source

Genome‐wide association study reveals the genetic architecture of drought tolerance in maize using yield‐based resistance indices and transcriptomic evidence

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Drought is a major environmental factor limiting maize (Zea mays L.) production worldwide. Unraveling the genetic basis of drought tolerance and pinpointing key loci and candidate genes are fundamental to the molecular breeding of maize with enhanced drought resistance.
Haoyang Li, Xurong Hu, Pengyan Zhang, Yueying Zhao, Yinglu Song, Zheng Zhang, Huahu Bu, Jianzhong Chang   +7 more
wiley   +1 more source

Inhibition of endocytosis by glycans arises from steric rather than electrostatic repulsion. [PDF]

Biophys J
Kamatar A, Villalobos JA, Hayden CC, Rodriguez Flores FG, Archer-Hartmann S, Azadi P, Belardi B, Parekh SH, Stachowiak JC.   +8 more
europepmc   +1 more source

The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin‐Dependent Kinase 5 to the Plasma Membrane

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Rebecca Flessner, Alina Ilie, Léo Han, Annie Boucher, Rebecca Anne McKinney, Reza Sharif‐Naeini, John Orlowski   +6 more
wiley   +1 more source

G6PD facilitates axon regeneration via clathrin-mediated endocytosis. [PDF]

J Biol Chem
Jiang C, Liu X, Li H, Lu Y, Cao Q, Yu B, Mao S.   +6 more
europepmc   +1 more source

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source