Results 11 to 20 of about 5,930 (178)

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields-treated glioblastoma, IDH wildtype patients. [PDF]

Brain Pathol
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Nückles J, Jelgersma C, Siewert C, Osberg B, Schmid S, Koch A, Perez E, Teichmann D, Misch M, Karbe AG, Ukrow S, Harter PN, Stassart RM, Vajkoczy P, Onken J, Capper D.   +15 more
europepmc   +2 more sources

RadioLigand Therapy with [¹⁷⁷Lu]Lu-PSMA-617 for Salivary Gland Cancers: Literature Review and First Compassionate Use in France

Pharmaceuticals, 2023
Salivary gland cancers are rare tumors comprising a large group of heterogeneous tumors with variable prognosis. Their therapeutic management at a metastatic stage is challenging due to the lack of therapeutic lines and the toxicity of treatments. [177Lu]
Marie Terroir, Chloé Lamesa, Mehdi Krim, Lavinia Vija, Jean-Sébastien Texier, Thibaut Cassou-Mounat, Jean-Pierre Delord, Delphine Vallot, Frédéric Courbon   +8 more
doaj   +1 more source

Pax Romana and the Roman “imperialism” in the 1st century A.D

RUDN Journal of World History, 2019
This article is devoted to such a historical phenomenon as the Roman imperialism in the epoch of Augustus and his coming successors. Despite the fact that the founder of the Principate had declared the coming of pax Augusta, he spent several wars of ...
Vladimir O. Nikishin
doaj   +1 more source

Immune microenvironment changes induced by neoadjuvant chemotherapy in triple-negative breast cancers: the MIMOSA-1 study

Breast Cancer Research, 2021
Background The immune microenvironment (IME) of triple-negative breast cancers (TNBCs) and its modulation by neoadjuvant chemotherapy (NACT) remain to be fully characterized.
Victor Sarradin, Amélie Lusque, Thomas Filleron, Florence Dalenc, Camille Franchet   +4 more
doaj   +1 more source

Management of tumor volume changes during preoperative radiotherapy for extremity soft tissue sarcoma: a new strategy of adaptive radiotherapy

Radiology and Oncology, 2023
Using adaptive radiotherapy (ART), to determine objective clinical criteria that identify extremity soft tissue sarcoma (ESTS) patients requiring adaptation of their preoperative radiotherapy (RT) plan.
De Lamarliere Marion Geneau, Lusque Amélie, Khalifa Justine Attal, Esteyrie Vincent, Chevreau Christine, Valentin Thibaud, Gangloff Dimitri, Meresse Thomas, Courtot Louis, Rochaix Philippe, Boulet Bérénice, Graulieres Eliane, Ducassou Anne   +12 more
doaj   +1 more source

Pseudoprogression in Glioblastoma: Role of Metabolic and Functional MRI-Systematic Review

Biomedicines, 2022
Background: Glioblastoma is the most frequent malignant primitive brain tumor in adults. The treatment includes surgery, radiotherapy, and chemotherapy.
Ingrid Sidibe, Fatima Tensaouti, Margaux Roques, Elizabeth Cohen-Jonathan-Moyal, Anne Laprie   +4 more
doaj   +1 more source

Does Next Generation Sequencing (NGS)-Based CYP2D6 Sequencing Improve Genotype-Phenotype Concordance in Tamoxifen-Treated Patients? [PDF]

Clin Pharmacol Ther
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Petit J, Plenecassagnes J, Brice A, Dalenc F, Mallet L, Chatelut E, Al Saati A, Thomas F.   +7 more
europepmc   +2 more sources

Multicentric phase II trial of TI‐CE high‐dose chemotherapy with therapeutic drug monitoring of carboplatin in patients with relapsed advanced germ cell tumors

Cancer Medicine, 2021
Background High‐dose chemotherapy (HDCT) with TI‐CE regimen is a valid option for the treatment of relapsed advanced germ cell tumors (GCT). We report a phase II trial with therapeutic drug monitoring of carboplatin for optimizing area under the curve ...
Christine Chevreau, Christophe Massard, Aude Flechon, Rémy Delva, Gwenaëlle Gravis, Jean‐Pierre Lotz, Jacques‐Olivier Bay, Marine Gross‐Goupil, Karim Fizazi, Loïc Mourey, Angelo Paci, Jérôme Guitton, Fabienne Thomas, Bénédicte Lelièvre, Joseph Ciccolini, Sotheara Moeung, Yohan Gallois, Pascale Olivier, Stéphane Culine, Thomas Filleron, Etienne Chatelut   +20 more
doaj   +1 more source

ÜÇ İMPARATORUN HAYATINDAKİ KADIN 'AGRİPPİNA MİNOR (İS 15-59)': İMPARATOR CALİGULA'NIN KIZ KARDEŞİ, İMPARATOR CLAUDİUS'UN KARISI, İMPARATOR NERO'NUN ANNESİ

History Studies
Agrippina Minor, soylu bir hanenin evladı, başarılarıyla ünlü olan komutan Germanicus’un kızı olarak dünyaya gelmişti. İmparator Tiberius tarafından 13 yaşında evlendirildiği ilk eşinden, daha sonra imparator olacak oğlu Lucius Domitius Ahenobarbus’u ...
Hüseyin Üreten, Ebru Durmaz Akyüz
doaj   +1 more source

The worship of the emperor in the image of Sobek-Souchos in Roman Egypt

RUDN Journal of World History
This study is devoted to the problem of the identification of the Roman emperor and god Sobek. The relevance of this issue lies in the fact that there is still no special scientific research devoted to this problem in academia.
Sergey A. Kachan
doaj   +1 more source