Results 21 to 30 of about 5,930 (178)

The GIRAFE phase II trial on MVCT-based “volumes of the day” and “dose of the day” addresses when and how to implement adaptive radiotherapy for locally advanced head and neck cancer

Clinical and Translational Radiation Oncology, 2019
During exclusive curative radiotherapy for head and neck tumors, the patient’s organs at risk (OAR) and target volumes frequently change size and shape, leading to a risk of higher toxicity and lower control than expected on planned dosimetry.
Vincent Esteyrie, Baptiste Gleyzolle, Amélie Lusque, Pierre Graff, Anouchka Modesto, Michel Rives, Michel Lapeyre, Jacques Desrousseaux, Eliane Graulières, Gregory Hangard, François-Xavier Arnaud, Regis Ferrand, Jean-Pierre Delord, Muriel Poublanc, Muriel Mounier, Thomas Filleron, Anne Laprie   +16 more
doaj   +1 more source

Impact of different models based on blood samples and images for bone marrow dosimetry after 177Lu-labeled somatostatin-receptor therapy

EJNMMI Physics
Background Peptide receptor radionuclide therapy with 177Lu-DOTATATE is a recognized option for treating neuroendocrine tumors and has few toxicities, except for the kidneys and bone marrow. The bone marrow dose is generally derived from a SPECT/CT image-
Delphine Vallot, Séverine Brillouet, Séléna Pondard, Lavinia Vija, Jean-Sébastien Texier, Lawrence Dierickx, Frédéric Courbon   +6 more
doaj   +1 more source

High density lipoprotein3 binding sites are related to DNA biosynthesis in the adenocarcinoma cell line A549

Journal of Lipid Research, 1993
The effect of high density (apoE-depleted HDL3) on cell growth of a human tumor cell line (A549) was studied and related to its binding on the plasma membrane.
G Favre, KA Tazi, F Le Gaillard, F Bennis, H Hachem, G Soula   +5 more
doaj   +1 more source

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

Safe Omission of Postoperative Neck Irradiation in Selected pN0 Patients With Locally Advanced Oral Cavity Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Postoperative radiotherapy is the standard treatment for locally advanced oral squamous cell carcinoma (OSCC); however, the indication for neck irradiation (NI) in pN0 patients remains debatable. We evaluated whether the omission of NI compromises outcomes in pT3–T4 pN0 patients treated with adequate neck dissection (ND).
Mathilde Mirallié, Anouchka Modesto, Marie Pajiep, Sébastien Vergez, Jérôme Sarini, Lucie Piram, Céline Dalmasso, Benjamin Vairel, Emilien Chabrillac, Agnès Dupret‐Bories   +9 more
wiley   +1 more source

Postoperative Hemoglobin and Transfusion Rates Do Not Influence Revision of Head and Neck Free Flap in a Cohort of 259 Patients

Head &Neck, EarlyView.
ABSTRACT Introduction Recent literature advocates restrictive transfusion thresholds (Hb < 7 g/dL). The aim of this study was to evaluate if postoperative hemoglobin levels and transfusions influence Free Flap Revision (FFR). Methods This single center retrospective study included all patients who underwent head and neck surgery with free flap ...
Olivier Gilbert, Agnès Dupret‐Bories, Olivier Staes, Guillaume Ducos, Luc Nguyen Van Phi, Claire Cabos, Muriel Picard, Charline Berthier, Mathilde Morisseau, Emilien Chabrillac   +9 more
wiley   +1 more source

Deep learning-enhanced digital-BGO versus TOF PET/CT: comparative assessment of detection, quantitation, and overall image quality

EJNMMI Physics
Background We evaluate the Omni Legend 32 cm (OMNI6R), a digital-BGO PET/CT using the deep learning (DL) based algorithm, Precision Deep Learning (PDL), emulating time-of-flight (TOF) enhancement and compare its performance to the TOF-equipped Discovery ...
Quentin Maronnier, Thibaut Cassou-Mounat, Erwan Gabiache, Adrien Latgé, Marie Terroir, Lavinia Vija, Kuan-Hao Su, Olivier Caselles, Frédéric Courbon   +8 more
doaj   +1 more source

Julian the Apostate, Claudius Mamertinus, and Ammianus Marcellinus: Filling in a “Blank Spot”?

Clotho, 2023
Flavius Claudius Julianus, often referred to as “Julian the Apostate,” ruled the Roman Empire from early 360 AD until his death in battle on June 26th, 363 AD.
Gregor Pobežin
doaj   +1 more source

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source

La carica del cavaliere. L’eco della battaglia del Ticino in Curt. VIII 1, 24

Erga-Logoi
The Horseman’s charge. The echo of the battle of Ticinus in Curt. VIII 1, 24  The episode in which Alexander the Great saves Philip II, narrated by Curtius Rufus, is not supported by other historical sources, raising doubts about its authenticity.
Alessandro Conte
doaj   +1 more source