Results 41 to 50 of about 1,749 (164)

Endophytic Fungi Natural Factories of Novel Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review provides a systematic analysis of 242 natural products isolated from 42 genera of endophytic fungi, highlighting their remarkable structural diversity and broad spectrum of biological activities . ABSTRACT Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological ...
Dilmurod Murodullayev, Jakhongir Movlanov, Liu Wei, Wei Liu, Maksud Isokov, Santosh Kumar Bose, Fazliddin Kobilov, Zamira Djumayeva, Buston Islamov, Jamila Sherkulova, Zafar Matyakubov, Muniskhon Meylieva, Munisa Ergasheva, Diyor Abduraxmanov, Guozheng Huang, Hongchen Jiang, Kakhramon Davranov, Guohui Pan, Nigora Rustamova   +18 more
wiley   +1 more source

Introduction to the Toxins Special Issue on Ergot Alkaloids

Toxins, 2015
Ergot alkaloids are among the most relevant natural products in the history of toxins and pharmaceuticals. Until the late 20th century, human and livestock exposure to ergot alkaloids was primarily through ingestion of “ergots,” which are spur-shaped or ...
Christopher L. Schardl
doaj   +1 more source

A Multi‐Target Approach to Colitis: Ergothioneine Promotes Recovery by Restoring the Intestinal Barrier, Reducing Inflammation, and Remodeling the Microbiota

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
In LPS‐induced Caco‐2 cells, EGT inhibits inflammatory cytokine overproduction and restores tight‐junction proteins. In DSS‐induced colitis mice, EGT alleviates colitis symptoms, lowers inflammatory mediators and immunoglobulins, and remodels gut microbiota.
Lin Wang, Yao Song, Yucong Wang, Zhixin Xie, Xihan Xu, Jianchun Han, Rongxu Liu   +6 more
wiley   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source

Collection and annotation statistics for the 24 Claviceps purpurea genomes used in this study.

, 2022
Collection and annotation statistics for the 24 Claviceps purpurea genomes used in this study.
Stephen Mondo (5117966), Stephen Wyka (12072220), Miao Liu (148274), Vamsi Nalam (12072223), Kirk Broders (660157)   +4 more
core   +1 more source

Mycotoxins in Basidiomycete Mycelium and Fruiting Bodies: Implications for Eu Novel Food Assessment and Selected International Regulatory Frameworks

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Advances in technology have enabled the efficient and sustainable production of basidiomycete vegetative mycelium, particularly from Pleurotus species, as a novel food source. However, mycelium has yet to receive regulatory approval in many global markets, requiring a better understanding of factors affecting its safety.
Niklas Erik Wilhelm Berglund, Pauliina Vappu Lankinen, Kirsi Susanna Mikkonen   +2 more
wiley   +1 more source

Occurrence and Health Risk Assessment of Aflatoxin B1 and Total Aflatoxins in Maize Flour From Jiroft City, Iran

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Aflatoxin B1 and total aflatoxins were assessed in 40 commercial maize flour samples collected from Jiroft City, Iran. AFB1 and total aflatoxins were detected in 67.5% and 70% of samples, respectively. A total of 35% of samples exceeded the EU limit for AFB1, while 20% exceeded the EU limit for total aflatoxins.
Zohreh Mashak, Ali Heshmati, Amir Sasan Mozaffari Nejad, Ali Asghar Kheirkhah Vakilabad, Saeme Asgari, Mohammad Mahdi Soori, Ali Habibi, Kasim Sakran Abass   +7 more
wiley   +1 more source

An Open‐Label, 2‐Period, Fixed Sequence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Single Doses of STS101 (Dihydroergotamine Nasal Powder), with and without Concomitant Itraconazole in Healthy Adult Subjects

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Dihydroergotamine (DHE) prescribing information contains a boxed warning regarding the possibility of serious and/or life‐threatening peripheral ischemia with co‐administration of strong cytochrome P450 3A4 (CYP3A4) inhibitors. The effects of the strong CYP3A4 inhibitor itraconazole on the pharmacokinetics and safety of nasally administered ...
Detlef Albrecht, Elizabeth Hussey, Richard B. Lipton   +2 more
wiley   +1 more source

Additional file 11 of Genome-wide analysis of Claviceps paspali: insights into the secretome of the main species causing ergot disease in Paspalum spp

, 2021
Additional file S11. Representation of CAZymes in each isolate of Claviceps analyzed in this work.
H. Oberti (8261559), S. Murchio (8261568), M. Feijoo (11609995), N. Cogan (11609992), M. Dalla-Rizza (11609998), R. Reyno (8261565), G. Spangenberg (11609989)   +6 more
core   +1 more source

Plants synthesize ergothioneine, showing a link to abiotic stress

Plant Biology, Volume 28, Issue 5, Page 1343-1348, August 2026.
Various plants possess ergothioneine biosynthetic genes and can synthesize this antioxidant, where increased EGT levels under abiotic stress conditions indicate protective functions. Abstract Ergothioneine (EGT) is a sulphur‐containing histidine derivative and a potent antioxidant that exhibits beneficial effects on human health.
C. Kock, N. Gutsche, S. Walter, S. Zachgo   +3 more
wiley   +1 more source