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Oral amoxicillin and amoxicillin–clavulanic acid: properties, indications and usage [PDF]

open access: yesClinical Microbiology and Infection, 2020
BACKGROUND: Amoxicillin has been in use since the 1970s; it is the most widely used penicillin both alone and in combination with the beta-lactamase clavulanic acid.
Angela Huttner, Niels Frimodt-Moller
exaly   +3 more sources

Degradation products of clavulanic acid promote clavulanic acid production in cultures of Streptomyces clavuligerus

open access: yesEnzyme and Microbial Technology, 2004
The role of clavulanic acid, an unstable antibiotic produced by Streptomyces clavuligerus, in biomass accumulation and production of clavulanic acid in batch cultures of the organism was examined. The organism was grown in a medium containing either 20 g/
Yang, Y., Lynch, H.C.
exaly   +2 more sources
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On the absorption of clavulanic acid

Biopharmaceutics & Drug Disposition, 1988
AbstractIt was not possible to computer fit oral clavulanic acid data using exponential or model equations incorporating a single exponential defining the absorption phase. Using the Loo‐Riegelman method three phases of the absorption process became apparent, an initial slow phase, a more rapid phase and a final slow phase, contributing approximately ...
G D, Allen, P E, Coates, B E, Davies
openaire   +2 more sources

Polarographic determination of clavulanic acid

Journal of Pharmaceutical and Biomedical Analysis, 1991
A method is proposed for the determination of clavulanic acid by differential pulse polarography. The electroactive product was obtained by hydrolysis in sulphuric medium. It shows a reduction peak, that can be used analytically, at -0.75 V (vs SCE).
C, González Pérez   +2 more
openaire   +2 more sources

The disposition of clavulanic acid in man

Xenobiotica, 1986
Following oral administration of potassium 14C-clavulanate to four human subjects, at least 73% of the radioactive dose was absorbed. The mean absolute bioavailability was 64%. Absorption was rapid with peak plasma concentrations of radioactivity and clavulanic acid (2-6 micrograms/ml) occurring between 45 min and three hours after dosing.
G C, Bolton   +4 more
openaire   +2 more sources

Biochemistry and Action of Clavulanic Acid

Scottish Medical Journal, 1982
The destruction of amoxycillin by β-lactamase action represents an important mechanism of bacterial resistance to the drug. Data is presented to illustrate that clavulanic acid used in the form of its potassium salt inhibits the amoxycillin destroying action of many different types of β-lactamase for example: the staphylococcal enzyme, the clinically ...
openaire   +2 more sources

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