Results 91 to 100 of about 47,494 (292)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Wear volumes of flowable and sculptable resin composite attachments and their correlation with retentive force of clear aligners: a laboratory study

BMC Oral Health
Background Aligner attachment integrity is important for clear aligner retention and overall treatment efficacy. This study aimed to evaluate the wear volume of clear aligner attachments and the retentive force change of clear aligners over a simulated ...
Nuttakan Roatkanjanaporn, Janeta Chavanavesh, Chutimont Teekavanich   +2 more
doaj   +1 more source

Management of the anterior open bite using clear aligner therapy and surgery-first: Case example and scoping review of the literature

Dentistry Review
Background: The anterior open bite is challenging skeletal facial discrepancy and often requires a combined orthodontic and surgical approach to treatment.
Marshall F. Newman, Joshua Stewart
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

An Update on 3D-printed Orthodontic Aligners [PDF]

Journal of Clinical and Diagnostic Research
Clear Aligner Treatment (CAT) is an orthodontic technique used to align teeth with removable and scarcely visible appliances. Conventionally, these are produced through the process of thermoforming.
Nazleen Valerie Vas, Ravindra Kumar Jain
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Biofilm Composition Changes During Orthodontic Clear Aligners Compared to Multibracket Appliances: A Systematic Review

Microorganisms
Clear aligner treatment seems to be a good option for the periodontal patient by the reason of being removable. Multibracket appliances are more difficult to mantain clean and some bacteria might prefer to adhere on the archwire.
Alba Belanche Monterde, Javier Flores-Fraile, Esteban Pérez Pevida, Álvaro Zubizarreta-Macho   +3 more
doaj   +1 more source

Orthodontic Treatment with Clear Aligners and The Scientific Reality Behind Their Marketing: A Literature Review

Turkish Journal of Orthodontics, 2019
As the demand for esthetic treatments is increasing, more people are seeking alternatives to fixed orthodontic appliances. Clear aligners are an esthetic and comfortable option for orthodontic treatment and have gained immense popularity over the last ...
İpek Tamer, Evren Öztaş, Gülnaz Marşan   +2 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source