Results 111 to 120 of about 4,057,216 (280)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

In Vitro Flexural Testing of Clear Aligner Materials: A Scoping Review of Methods, Results, and Clinical Relevance

Applied Sciences
Background: Clear aligner therapy (CAT) has become increasingly popular for treating mild to moderate malocclusions. However, discrepancies between predicted and achieved tooth movement remain a concern, partly due to the limited understanding of aligner
Gavin Nugent, Alvaro Munoz, Chris Louca, Alessandro Vichi   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Wear volumes of flowable and sculptable resin composite attachments and their correlation with retentive force of clear aligners: a laboratory study

BMC Oral Health
Background Aligner attachment integrity is important for clear aligner retention and overall treatment efficacy. This study aimed to evaluate the wear volume of clear aligner attachments and the retentive force change of clear aligners over a simulated ...
Nuttakan Roatkanjanaporn, Janeta Chavanavesh, Chutimont Teekavanich   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

CLEAR ALIGNER TREATMENT PLANNING

Clear aligner treatment planning is a critical component of contemporary orthodontic practice, combining digital technology, biomechanical principles, and individualized patient assessment to achieve predictable tooth movement and optimal treatment ...
Dr. Shradha Suman Mishra, Dr. Poonam Singh, Dr. Amit Bhardwaj, Dr. Kratika Mishra, Dr. Jeenal Gupta   +4 more
core   +1 more source

digitallinguistics/word-aligner: v0.1.0

, 2020
The initial release of the word-aligner ...
Daniel W. Hieber
core   +1 more source

The current landscape of clear aligner usage: A KAP survey among orthodontists and dental practitioners

Indian Journal of Dental Research
Background: Clear aligner therapy (CAT) adoption varies among practitioners. Methods: Cross-sectional validated survey among 112 practitioners (orthodontists & general dentists). Descriptive and inferential analysis via SPSS. Results: Mean age 33.97 yrs;
Greeshma Shantaram Gothankar, Jitendar Machawal, Sunil Kumari Sen, Garima Arora, Shailendra Singh Rana   +4 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Biomechanical Response To Crown-Root Angular In Clear Aligner Therapy

International Dental Journal
Aim or purpose: The maxillary canine plays a critical biomechanical role in maintaining archform integrity and functional occlusion.The accuracy of clear aligners (CA) for canine movement depends on anatomical factors, particularly the crown-root angle ...
Xinwei Lyu, Jiali Tan, Cheng Hu, Yuqian Li, Tian Yang, Liping Liu, Siyuan Ma   +6 more
doaj   +1 more source