Results 91 to 100 of about 4,057,216 (280)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Impacts of fixed orthodontic appliance and clear-aligner on daily performance in adult patients with moderate need for treatment

, 2016
Feiou Lin,1 Linjie Yao,2 Chandradev Bhikoo,1 Jing Guo3 1Department of Orthodontics, 2Department of Pedodontics, School of Stomatology, Wenzhou Medical University, Wenzhou, 3Department of Orthodontics, School and Hospital of Stomatology, Shandong ...
Yao L, Bhikoo C, Guo J, Lin F
core  

Patient satisfaction and compliance with clear aligner therapy during treatment

Introduction: This study compared patient satisfaction between both clear aligner and traditional fixed appliance treatment. This study also explored patient compliance with both treatment modalities, outcomes, and overall satisfaction.
Fischer, Luke
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

BIOMECHANICS OF CLEAR ALIGNER

The biomechanics of clear aligners plays a crucial role in determining the efficiency, predictability, and success of orthodontic tooth movement during aligner therapy.
Dr. Poonam Singh, Dr. Amit Bhardwaj, Dr. Kratika Mishra, Dr. Jeenal Gupta, Dr. Nupur Uskar   +4 more
core   +1 more source

Class II correction with Carriere Motion 3D Appliance and clear aligner therapy

, 2022
Clear aligner therapy has been shown to be effective in resolving mild to moderate malocclusions, with shorter treatment and less chairtime compared to conventional systems.1 To overcome some of the aligners’ bio­mechanical limitations while still ...
Oliverio, Teresa, Lombardo, Luca, Siciliani, Giuseppe, Cremonini, Francesca, Cervinara, Francesca   +4 more
core  

Evaluation of Tooth Movement Accuracy with the F22 Aligner System: A Retrospective Study

Applied Sciences
Background: To investigate the accuracy of an F22 Aligner system, considering the amount of prescribed movement, tooth type, grip points, sex and age. Methods: Digital models of 120 patients (64 females and 56 males; mean age 35.2 years ± 7.4) affected ...
Palone Mario, Silvia Squeo de Villagomez, Pellitteri Federica, Francesca Cremonini, Renato Salvatore, Luca Lombardo   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Effect of Initial Orthodontic Therapy with Clear Aligners and Fixed Appliances on Microbial Profiles and Clinical Parameters

Journal of the California Dental Association
Background Orthodontic appliances hinder proper oral hygiene, leading to plaque retention and biofilm formation which can cause dental diseases. This study investigates the initial impact of orthodontic treatment with fixed appliances versus clear ...
Megan Haug, Andrew Hopkins, Emily Duong, Kim-Sa Kelly, Julia Esfandi, Bhumika Shokeen, Tingxi Wu, Renate Lux   +7 more
doaj   +1 more source

Clear aligner therapy combined with orthognathic surgery: A scoping review

American Journal of Orthodontics and Dentofacial Orthopedics
It is uncertain whether using perioperative clear aligner therapy (CAT) for orthognathic surgery (OGS) is a suitable alternative to conventional fixed appliances, which has traditionally been the mainstay of orthodontic preparation and refinement. This scoping review assesses the nature of current evidence regarding the use of CAT with OGS.The review ...
Alex Simon Chan, Lyn Jiang, Josh Ch’ng, Seth Delpachitra   +3 more
openaire   +3 more sources