Results 101 to 110 of about 4,057,216 (280)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Festival of the Ten Days to Rendezvous information sheet [PDF]

, 2016
8.5” x 11”Typed information sheet for the Festival of the Ten Days to Rendezvous sponsored by the Clear Lake Chamber of ...

core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Rancang Bangun Aplikasi Optimasi Tahapan Clear Aligner Dan Pencetakan 3D Clear Aligner

, 2023
Clear aligner adalah teknologi pengganti perawatan kawat pada gigi. Umumnya pasien yang melakukan perawatan kawat pada gigi mengalami kesulitan untuk membersihkan gigi dan adanya gangguan saat makan ataupun minum.
Sihaj, Gerry
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluation of effects of different sizes and shapes of attachments during rotation, tipping, and torquing in clear aligner therapy – A finite element study

Journal of Orthodontic Science
OBJECTIVE: To evaluate the effect of different shapes and sizes of attachments used for rotation, tipping, and torquing tooth movement in clear aligner therapy. MATERIAL AND METHODS: Using computer-aided design/computer-aided manufacturing technology, 15
Krutadnya Pede, Pravin Shetty, Alok Ranjan, Waseem Khan, Harshal Patil, Harsh Mishra   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

The Effects of Light and Vibration on the Correction of Lower Incisor Crowding with Aligners

Turkish Journal of Orthodontics
Objective: To compare the effects of low-frequency vibration (LFV), photobiomodulation (PBM), and their combination (HOT) on the rate of mandibular incisor alignment during clear aligner therapy.
Mustafa Özcan, Didem Nalbantgil
doaj   +1 more source

Enhancing Clear Aligners Therapy with Artificial Intelligence and Technology

Journal of Pharmacy and Bioallied Sciences
ABSTRACT Background: The efficacy of clear aligner therapy (CAT) in the management of malocclusion is largely dependent on patient compliance, especially the proper use of aligners. Objective: The present study investigated the influence of an artificial intelligence (AI) mobile application ...
openaire   +2 more sources