Results 121 to 130 of about 250,661 (348)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Efficacy and safety of lenvatinib plus pembrolizumab vs sunitinib in the East Asian subset of patients with advanced renal cell carcinoma from the CLEAR trial [PDF]

, 2023
Sun Young Rha, Toni K. Choueiri, В. Б. Матвеев, Anna Alyasova, Sung‐Hoo Hong, Teresa Alonso Gordoa, Howard Gurney, Georg A. Bjarnason, Tomáš Büchler, Paolo Pedrazzoli, Toshio Takagi, Se Hoon Park, Jae‐Lyun Lee, Rodolfo F. Perini, Cixin He, Jodi A. McKenzie, Masatoshi Eto   +16 more
openalex   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Case report: A collision tumor of clear cell renal cell carcinoma and clear cell papillary renal cell tumor

Frontiers in Oncology
We report the case of a 51-year-old woman who was initially hospitalized in the respiratory department with cough and fever. Urinary computed tomography (CT) showed two different incidental masses in the right kidney.
Yingsheng Lin, Yingsheng Lin, Jinan Guo, Zaishang Li, Zengqin Liu, Jing Xie, Junxu Liu, Hongtao Jin, Kefeng Xiao   +8 more
doaj   +1 more source

Primary Clear Cell Renal Cell Carcinoma with Marked Intraluminal Mucin Secretion

Türk Patoloji Dergisi, 2019
Clear cell renal cell carcinoma with mucin secretion is an unexpected situation. Primary renal adenocarcinoma and various metastatic carcinomas should be considered in the differential diagnosis.
Oğuzhan OKCU, Kemal BEHZATOĞLU, Yasemin ÇAKIR, Esra PAŞAOĞLU, Uğur YÜCETAŞ   +4 more
doaj   +1 more source

Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma [PDF]

, 2023
Ana Dunatov Huljev, Nela Kelam, Benjamin Benzon, Violeta Šoljić, Natalija Filipović, Valdi Pešutić Pisac, Merica Glavina Durdov, Katarina Vukojević   +7 more
openalex   +1 more source

Three‐Year Follow‐Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer‐Associated Fibroblast Heterogeneity Corresponding to PD‐1 Blockade Efficacy

Advanced Science, EarlyView.
Heterogeneous cancer‐associated fibroblasts orchestrate dual immune microenvironments in LAGC. Abstract The potential for immunotherapy in patients with locally advanced gastric cancer (LAGC) is recently confirmed. To report the 3‐year follow‐up data are aimed from a novel clinical trial. This is a prospective single‐arm phase II trial.
Yao Lin, Xiong Sun, Chengguo Li, Ming Yang, Ke Wu, Ke Liu, Anshu Li, Xiaoming Shuai, Kailin Cai, Zheng Wang, Guobin Wang, Peng Zhang, Jianfeng Shen, Kaixiong Tao, Yuping Yin   +14 more
wiley   +1 more source

Bilateral synchronous renal cell carcinoma: a case report [PDF]

, 1995
55歳男.人間ドックで偶然みつかった両側同時性腎細胞癌(両側ともTl)に対し, 右腎摘出術及び左腎部分切除術を施行した例A case of bilateral synchronous renal cell carcinoma is reported. The patient was a 55-year-old man.
中村, 靖夫, 伊藤, 秀明, 大川, 光央, 徳永, 周二, 松井, 晃   +4 more
core  

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

An epithelial-mesenchymal transition-related long non-coding RNA signature to predict overall survival and immune microenvironment in kidney renal clear cell carcinoma

, 2021
Youpeng Zhang, Yongbiao Cheng, Sen Li, Ning Zhao, Zhaohui Zhu   +4 more
openalex   +1 more source