Results 141 to 150 of about 8,019,599 (294)
Advanced Science, EarlyView.TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen +10 more
wiley +1 more source
Advanced Science, EarlyView.An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu +10 more
wiley +1 more source
The relationship between renal cell carcinoma pathological types and perirenal fat area
BMC CancerIntroduction To explore whether there is a relationship between perirenal fat area (PFA) and the pathological types of renal cell carcinoma (RCC). Methods Two hundred ninety-seven cases of RCC patients were included in our study, which is a retrospective
Xin Leng +7 more
doaj +1 more source
Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer
Advanced Science, EarlyView.Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian +11 more
wiley +1 more source
MiR-935 Promotes Clear Cell Renal Cell Carcinoma Migration and Invasion by Targeting IREB2
Cancer Management and Research, 2019 Fei Liu,1,2 Yuedong Chen,2 Bin Chen,2 Chunxiao Liu,1 Jinchun Xing2 1Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou 510280, People’s Republic of China; 2Department of Urology, The First Affiliated Hospital of ...
Liu F, Chen Y, Chen B, Liu C, Xing J
doaj
Advanced Science, EarlyView.This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen +10 more
wiley +1 more source
Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors
Advanced Science, EarlyView.Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici +4 more
wiley +1 more source
, 2008 Renal cell carcinoma (RCC) is the most common malignancy in adult kidney, and accounts for 3% of malignancies worldwide with increasing incidence. Clear cell RCC (ccRCC) is the major type in RCC.
TANG, SAI-WEN;CHANG, WEN-HSIN;CHAO, YU- WEI;LAI, YEN-HAN;HSU, CHYONG-ING;LIN, WEI-CHOU;WANG, KAO-CHUNG;LAI, MING-KUEN;LIN, JUNG-YAW +1 more
core
Advanced Science, EarlyView.Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li +8 more
wiley +1 more source