Results 121 to 130 of about 8,019,599 (294)

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Co-insidental, Ipsilateral Renal Cell Carcinoma and Urothelial Carcinoma of Ureter: A Rare Case

, 2016
Renal cell carcinoma and urothelial carcinoma of the upper urinary tract are not rare urological malignancies, however, in a patient with renal cell carcinoma and urothelial carcinoma seen simultaneously in the same kidney is a rare event.
Tarık Yonguç, Özgü Aydoğdu, Volkan Şen, İbrahim Halil Bozkurt, Tansu Değirmenci, İbrahim Küçüktürkmen, Bozkurt, İbrahim Halil, KÜÇÜKTÜRKMEN, İBRAHİM, YONGUÇ, TARIK, AYDOĞDU, ÖZGÜ, ŞEN, VOLKAN, DEĞİRMENCİ, TANSU   +11 more
core   +1 more source

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source

A Case Report of Renal Cell Carcinoma Producing Alpha-Fetoprotein [PDF]

, 1992
We report a rare autopsy case of alpha-fetoprotein producing renal cell carcinoma with multiple metastases to liver, gallbladder, mesenterium, and paraaortic lymphnodes. A 58-year-old male patient was diagnosed as having carcinoma of the right kidney. On
Kiyuna, Masaya, Toda, Takayoshi, Shimajiri, Shouhei, Sasi, Ai Muktafi, Tamamoto, Tooru, Shingaki, Yoshisada, Hayakawa, Masamichi   +6 more
core  

Bladder Metastasis from Clear Cell Renal Cell Carcinoma: A Case Report

Caucasian Medical Journal
Kidney cancer is one of the most common urologic cancers. Generally, kidney cancer metastases occur in the liver, lungs, and bones, but we can see rare metastases such as those in the urinary bladder.
İlkin Hamid-Zada, Mammad Khalilov, Özgür Efiloğlu, Asıf Yıldırım   +3 more
doaj   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Representative histological images of renal cell carcinoma.

, 2013
(A) Clear cell renal cell carcinoma, and (B) chromophobe renal cell carcinoma.
Vera L. Costa (118874), Maria L. Bastos (352075), Félix Carvalho (336629), Márcia Carvalho (352081), Rui Henrique (33490), Carmen Jerónimo (33496), Paula Guedes de Pinho (352078), Maria João Valente (352073)   +7 more
core   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Clear Cell Renal Cell Carcinoma 2022–2023

Clear cell renal cell carcinoma is a common tumor in Western countries and an appropriate test subject for new therapies. This Special Issue highlights the most up-to-date research into clear cell renal cell carcinoma from different medical perspectives,

core   +1 more source